Compounds That Target HTR2C

5-hydroxytryptamine receptor 2C · 280 compounds in BiohacksAI corpus

HTR2C (5-hydroxytryptamine receptor 2C) is a receptor that mediates ligand-dependent signaling relevant to physiology, behavior, and metabolism. The 280 compounds with documented HTR2C interactions span synthetic agonists, antagonists, and natural ligands identified through BindingDB binding assays and PubMed literature in the BiohacksAI corpus.

View HTR2C target page →UniProt: P28335 ↗

Most Studied Compounds for HTR2C

Mianserin

299+

studies

Aripiprazole

298+

studies

All 50 Compounds — Ranked by Evidence

Tamoxifen

5.88

confidence

Clozapine

5.81

confidence

Imipramine

5.69

confidence

Serotonin

5.47

confidence

Nifedipine

5.34

confidence

8 Oh Dpat

4.98

confidence

Risperidone

4.89

confidence

Ketanserin

4.85

confidence

Ly 294002

4.84

confidence

Raloxifene

4.77

confidence

Terfenadine

4.55

confidence

Propafenone

4.53

confidence

Thioridazine

4.52

confidence

Amiodarone

4.51

confidence

Olanzapine

4.44

confidence

Citalopram

4.36

confidence

Clomipramine

4.28

confidence

Spiperone

4.23

confidence

Diphenhydramine

4.22

confidence

Promazine

4.19

confidence

Pyrilamine

4.17

confidence

Diethylstilbestrol

4.06

confidence

Propofol

4.01

confidence

Ib Meca

4.01

confidence

Ziprasidone

3.99

confidence

Namodenoson

3.95

confidence

Fluphenazine

3.91

confidence

Salmeterol

3.76

confidence

Amentoflavone

3.76

confidence

Ritanserin

3.61

confidence

Lysergide

3.61

confidence

Sertindole

3.58

confidence

Tryptamine

3.56

confidence

Doxazosin

3.53

confidence

Doxepin

3.50

confidence

Ketotifen

3.47

confidence

Mirtazapine

3.43

confidence

Chlorophenylpiperazine

3.37

confidence

Prochlorperazine

3.33

confidence

Mebufotenin

3.33

confidence

Agomelatine

3.33

confidence

Droperidol

3.30

confidence

Desloratadine

3.26

confidence

Azelastine

3.26

confidence

5 Methoxytryptamine

3.18

confidence

Purvalanola

3.18

confidence

Mesulergine

3.18

confidence

Phenothiazine

3.14

confidence

Aripiprazole

298+

studies

3.04

confidence

Mianserin

299+

studies

3.00

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for HTR2C (5-hydroxytryptamine receptor 2C). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: HTR2C target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.