Compounds That Target NLRP3

NLR family pyrin domain containing 3 · 136 compounds in BiohacksAI corpus

NLRP3 (NLR family pyrin domain containing 3) is a biological target with 136 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into NLRP3 modulation for therapeutic and biohacking applications.

View NLRP3 target page →UniProt: AAI43360 ↗

Most Studied Compounds for NLRP3

Curcuma Longa

500+

studies

Centella Asiatica

499+

studies

Lithocholic Acid

300+

studies

Hexachlorophene

300+

studies

Androsterone

300+

studies

Cycloheximide

300+

studies

Etiocholanolone

300+

studies

Calcitriol

300+

studies

Dihydrotestosterone

300+

studies

Ethinyl Estradiol

300+

studies

All 54 Compounds — Ranked by Evidence

Isoliquiritigenin

4.50

confidence

Micheliolide

2.08

confidence

Niclosamideorganic

1.61

confidence

Lithocholic Acid

300+

studies

1.61

confidence

Hexachlorophene

300+

studies

1.61

confidence

Androsterone

300+

studies

1.61

confidence

Cycloheximide

300+

studies

1.61

confidence

Etiocholanolone

300+

studies

1.61

confidence

Dimethyl Fumarate

296+

studies

1.61

confidence

Tyrphostin 9

studies

1.61

confidence

Thioridazine Hydrochloride

35+

studies

1.39

confidence

Calcitriol

300+

studies

1.39

confidence

Dihydrotestosterone

300+

studies

1.39

confidence

Ethinyl Estradiol

300+

studies

1.39

confidence

Oridonin

300+

studies

1.10

confidence

20 Alpha Dihydroprogesterone

224+

studies

1.10

confidence

Anisomycin

247+

studies

1.10

confidence

Chlorhexidine

299+

studies

1.10

confidence

Tocainide

299+

studies

1.10

confidence

Panax Ginseng

300+

studies

1.00

confidence

Litchi Chinensis

1.00

confidence

Lobelia Chinensis

1.00

confidence

Lonicera Japonica

1.00

confidence

Nelumbo Nucifera

1.00

confidence

Agastache Rugosa

1.00

confidence

Allium Tuberosum

1.00

confidence

Aloe Vera

1.00

confidence

Anemarrhena Asphodeloides

1.00

confidence

Artemisia Argyi

1.00

confidence

Artemisia Capillaris

1.00

confidence

Aster Tataricus

1.00

confidence

Atractylodes Macrocephala

1.00

confidence

Bupleurum Chinense

1.00

confidence

Carthamus Tinctorius

1.00

confidence

Centella Asiatica

499+

studies

1.00

confidence

Chaenomeles Speciosa

1.00

confidence

Citrus Reticulata

1.00

confidence

Curcuma Longa

500+

studies

1.00

confidence

Cuscuta Chinensis

1.00

confidence

Cynomorium Songaricum

1.00

confidence

Dimocarpus Longan

1.00

confidence

Ephedra Sinica

1.00

confidence

Epimedium Brevicornum

1.00

confidence

Eriobotrya Japonica

1.00

confidence

Eucommia Ulmoides

1.00

confidence

Fritillaria Cirrhosa

1.00

confidence

Ginkgo Biloba

299+

studies

1.00

confidence

Glycine Max

1.00

confidence

Glycyrrhiza Uralensis

1.00

confidence

Ligusticum Chuanxiong

1.00

confidence

Riluzole

298+

studies

0.69

confidence

Glyburide

298+

studies

0.69

confidence

Disulfiram

297+

studies

0.69

confidence

Bortezomib

300+

studies

0.69

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for NLRP3 (NLR family pyrin domain containing 3). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: NLRP3 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.