BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/PLK1/Compounds

Compounds That Target PLK1

polo like kinase 1 · 38 compounds in BiohacksAI corpus

PLK1 (polo like kinase 1) is a biological target with 38 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into PLK1 modulation for therapeutic and biohacking applications.

View PLK1 target page →UniProt: P53350 ↗
Most Studied Compounds for PLK1
1
Simvastatin
1.0k+
studies
2
Wortmannin
300+
studies
3
Quercetin
300+
studies
4
Hexachlorophene
300+
studies
5
Lithocholic Acid
300+
studies
6
Oxyphenbutazone
300+
studies
7
Oxytetracycline
300+
studies
8
Cefaclor
299+
studies
9
Disulfiram
297+
studies
10
Oleic Acid
112+
studies
All 38 Compounds — Ranked by Evidence
1
Ly 294002
4.84
confidence
2
Morin
4.28
confidence
3
Ruxolitinib
4.23
confidence
4
Bosutinib
4.08
confidence
5
Bi 2536
4.01
confidence
6
Baicalin
3.91
confidence
7
Brigatinib
3.81
confidence
8
Silmitasertib
3.78
confidence
9
Tae 684
3.43
confidence
10
Fedratinib
3.40
confidence
11
Mln 8054
3.33
confidence
12
Jnj 7706621
3.09
confidence
13
Lestaurtinib
3.04
confidence
14
Adavosertib
3.04
confidence
15
Danusertib
2.94
confidence
16
Volasertib
2.94
confidence
17
Thymoquinone
2.89
confidence
18
R 406
2.83
confidence
19
Gsk 461364
2.40
confidence
20
Azd 6482
2.30
confidence
21
Rigosertib
2.30
confidence
22
Norlichexanthone
1.79
confidence
23
Gw843682x
1.79
confidence
24
Ly294002
11+
studies
1.61
confidence
25
Wortmannin
300+
studies
1.61
confidence
26
Myricetinflavonoids
0.69
confidence
27
Oleic Acid
112+
studies
0.69
confidence
28
Quercetin
300+
studies
0.69
confidence
29
Simvastatin
1.0k+
studies
0.69
confidence
30
Cefaclor
299+
studies
0.69
confidence
31
Disulfiram
297+
studies
0.69
confidence
32
Hexachlorophene
300+
studies
0.69
confidence
33
Lithocholic Acid
300+
studies
0.69
confidence
34
Nisoldipinedrugage
0.69
confidence
35
Oxyphenbutazone
300+
studies
0.69
confidence
36
Oxytetracycline
300+
studies
0.69
confidence
37
Bdb Chembl3401984
2+
studies
0.69
confidence
38
Bdb Chembl3401987
2+
studies
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for PLK1 (polo like kinase 1). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: PLK1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.