BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/POLB/Compounds

Compounds That Target POLB

DNA polymerase beta · 151 compounds in BiohacksAI corpus

POLB (DNA polymerase beta) is a biological target with 151 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into POLB modulation for therapeutic and biohacking applications.

View POLB target page →UniProt: P06746 ↗
Most Studied Compounds for POLB
1
Syzygium Aromaticum
500+
studies
2
Allium Sativum
500+
studies
3
Centella Asiatica
499+
studies
4
Foeniculum Vulgare
499+
studies
5
Stigmasterol
300+
studies
6
Oleanolic Acid
300+
studies
7
Protocatechuic Acid
300+
studies
8
Ursolic Acid
300+
studies
9
Panax Ginseng
300+
studies
10
Calycosin
300+
studies
All 60 Compounds — Ranked by Evidence
1
Betulinic Acid
5.21
confidence
2
Beta Sitosterol
3.95
confidence
3
Corosolic Acid
3.40
confidence
4
Zidovudine Triphosphate
3.18
confidence
5
Ilimaquinone
2.71
confidence
6
Pamoic Acid
2.30
confidence
7
Stigmasterol
300+
studies
1.95
confidence
8
Oleanolic Acid
300+
studies
1.95
confidence
9
Protocatechuic Acid
300+
studies
1.61
confidence
10
Methyldopa
297+
studies
1.10
confidence
11
Ursolic Acid
300+
studies
1.10
confidence
12
Smilax Glabra
1.00
confidence
13
Syzygium Aromaticum
500+
studies
1.00
confidence
14
Verbena Officinalis
1.00
confidence
15
Ziziphus Jujuba
1.00
confidence
16
Achyranthes Bidentata
1.00
confidence
17
Agastache Rugosa
1.00
confidence
18
Allium Sativum
500+
studies
1.00
confidence
19
Centella Asiatica
499+
studies
1.00
confidence
20
Chaenomeles Speciosa
1.00
confidence
21
Crataegus Pinnatifida
1.00
confidence
22
Eriobotrya Japonica
1.00
confidence
23
Eucommia Ulmoides
1.00
confidence
24
Foeniculum Vulgare
499+
studies
1.00
confidence
25
Forsythia Suspensa
1.00
confidence
26
Gentiana Macrophylla
1.00
confidence
27
Glycyrrhiza Uralensis
1.00
confidence
28
Lithospermum Erythrorhizon
1.00
confidence
29
Nelumbo Nucifera
1.00
confidence
30
Morus Alba
1.00
confidence
31
Panax Ginseng
300+
studies
1.00
confidence
32
Panax Notoginseng
1.00
confidence
33
Perilla Frutescens
1.00
confidence
34
Platycodon Grandiflorus
1.00
confidence
35
Prunella Vulgaris
1.00
confidence
36
Rubia Cordifolia
200+
studies
1.00
confidence
37
Salvia Miltiorrhiza
1.00
confidence
38
Schisandra Chinensis
1.00
confidence
39
Scutellaria Baicalensis
1.00
confidence
40
Smilax China
142+
studies
1.00
confidence
41
Amethopterin
289+
studies
0.69
confidence
42
Calycosin
300+
studies
0.69
confidence
43
Demeclocycline Hydrochloride
5+
studies
0.69
confidence
44
Dequalinium Chloride
46+
studies
0.69
confidence
45
Emodin
300+
studies
0.69
confidence
46
Hexachlorophene
300+
studies
0.69
confidence
47
Idarubicin
299+
studies
0.69
confidence
48
Oxytetracycline
300+
studies
0.69
confidence
49
Piceatannoldrugage
0.69
confidence
50
Sodium Nitroprusside
299+
studies
0.69
confidence
51
Sp600125
117+
studies
0.69
confidence
52
Stavudine
298+
studies
0.69
confidence
53
Streptonigrin
299+
studies
0.69
confidence
54
Taxifolin
300+
studies
0.69
confidence
55
Thioctic Acid
300+
studies
0.69
confidence
56
Ala
169+
studies
0.69
confidence
57
Alpha Lipoic Acid
169+
studies
0.69
confidence
58
Egcg
300+
studies
0.69
confidence
59
Luteolin
150+
studies
0.69
confidence
60
Methylene Blue
200+
studies
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for POLB (DNA polymerase beta). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: POLB target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.