Compounds That Target PRKAA2

protein kinase AMP-activated catalytic subunit alpha 2 · 136 compounds in BiohacksAI corpus

PRKAA2 encodes the catalytic alpha-2 subunit of AMPK, predominantly expressed in skeletal muscle and cardiac tissue. It plays a critical role in exercise adaptation, glucose transport, and metabolic flexibility. Activation of the PRKAA2 isoform is particularly relevant for sports performance and metabolic health research. The 136 compounds below include both pharmaceutical agents and natural compounds with evidence of PRKAA2 interaction.

View PRKAA2 target page →UniProt: P54646 ↗

Most Studied Compounds for PRKAA2

Curcuma Longa

500+

studies

Adenosine Monophosphate

300+

studies

Quercetin

300+

studies

Berberine

300+

studies

Ursolic Acid

300+

studies

Antimycin A

300+

studies

Oleanolic Acid

300+

studies

Rotenone

300+

studies

Panax Ginseng

300+

studies

Proguanil

299+

studies

All 50 Compounds — Ranked by Evidence

Foretinib

4.34

confidence

Tozasertib

4.33

confidence

Midostaurin

3.85

confidence

Nintedanib

3.61

confidence

Tae 684

3.43

confidence

Fedratinib

3.40

confidence

Dorsomorphin

3.14

confidence

Dovitinib

3.09

confidence

Jnj 7706621

3.09

confidence

Lestaurtinib

3.04

confidence

R 406

2.83

confidence

Pha 665752

2.71

confidence

Kw 2449

2.64

confidence

Ebastine

2.64

confidence

Bms 754807

2.30

confidence

Su 014813

2.20

confidence

Enzastaurin

2.08

confidence

Adenosine Monophosphate

300+

studies

1.95

confidence

Proguanil

299+

studies

1.95

confidence

Proanthocyanidin A1

1.95

confidence

Fccp

76+

studies

1.61

confidence

Quercetin

300+

studies

1.39

confidence

Niclosamideorganic

1.39

confidence

Berberine

300+

studies

1.10

confidence

Ursolic Acid

300+

studies

1.10

confidence

Antimycin A

300+

studies

1.10

confidence

Oleanolic Acid

300+

studies

1.10

confidence

Rotenone

300+

studies

1.10

confidence

Agastache Rugosa

1.00

confidence

Allium Tuberosum

1.00

confidence

Aloe Vera

1.00

confidence

Artemisia Capillaris

1.00

confidence

Aster Tataricus

1.00

confidence

Bupleurum Chinense

1.00

confidence

Chaenomeles Speciosa

1.00

confidence

Citrus Reticulata

1.00

confidence

Curcuma Longa

500+

studies

1.00

confidence

Ephedra Sinica

1.00

confidence

Eriobotrya Japonica

1.00

confidence

Forsythia Suspensa

1.00

confidence

Gastrodia Elata

1.00

confidence

Litchi Chinensis

1.00

confidence

Lithospermum Erythrorhizon

1.00

confidence

Lonicera Japonica

1.00

confidence

Morus Alba

1.00

confidence

Nelumbo Nucifera

1.00

confidence

Paeonia Lactiflora

1.00

confidence

Panax Ginseng

300+

studies

1.00

confidence

Panax Notoginseng

1.00

confidence

Perilla Frutescens

1.00

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: PRKAA2 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.