BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/TOP1/Compounds

Compounds That Target TOP1

DNA topoisomerase I · 137 compounds in BiohacksAI corpus

TOP1 (DNA topoisomerase I) is a biological target with 137 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into TOP1 modulation for therapeutic and biohacking applications.

View TOP1 target page →UniProt: P11387 ↗
Most Studied Compounds for TOP1
1
Allium Sativum
500+
studies
2
Curcuma Longa
500+
studies
3
Centella Asiatica
499+
studies
4
Foeniculum Vulgare
499+
studies
5
Camptothecin
300+
studies
6
Topotecan
300+
studies
7
Ethidium Bromide
300+
studies
8
Ginkgo Biloba
299+
studies
9
Irinotecan
298+
studies
10
Juglone
279+
studies
All 50 Compounds — Ranked by Evidence
1
Camptothecin
300+
studies
4.93
confidence
2
Amsacrine
4.82
confidence
3
Norharmane
3.76
confidence
4
Stallimycin
3.33
confidence
5
Topotecan
300+
studies
3.26
confidence
6
Hoechst 33258
3.09
confidence
7
Hymenialdisine
3.00
confidence
8
Corilagin
2.89
confidence
9
Acetylshikonin
2.48
confidence
10
Ungeremine
2.20
confidence
11
Isobutylshikonin
2.08
confidence
12
Irinotecan
298+
studies
1.79
confidence
13
Ethidium Bromide
300+
studies
1.61
confidence
14
Luteolin
150+
studies
1.10
confidence
15
Juglone
279+
studies
1.10
confidence
16
Achyranthes Bidentata
1.00
confidence
17
Agastache Rugosa
1.00
confidence
18
Allium Sativum
500+
studies
1.00
confidence
19
Aloe Vera
1.00
confidence
20
Arctium Lappa
1.00
confidence
21
Artemisia Annua
1.00
confidence
22
Artemisia Argyi
1.00
confidence
23
Artemisia Capillaris
1.00
confidence
24
Aster Tataricus
1.00
confidence
25
Atractylodes Macrocephala
1.00
confidence
26
Bletilla Striata
1.00
confidence
27
Centella Asiatica
499+
studies
1.00
confidence
28
Chaenomeles Speciosa
1.00
confidence
29
Cimicifuga Heracleifolia
1.00
confidence
30
Citrus Reticulata
1.00
confidence
31
Cnidium Monnieri
1.00
confidence
32
Crataegus Pinnatifida
1.00
confidence
33
Curculigo Orchioides
116+
studies
1.00
confidence
34
Curcuma Longa
500+
studies
1.00
confidence
35
Cuscuta Chinensis
1.00
confidence
36
Cynomorium Songaricum
1.00
confidence
37
Ephedra Sinica
1.00
confidence
38
Eriobotrya Japonica
1.00
confidence
39
Eucommia Ulmoides
1.00
confidence
40
Foeniculum Vulgare
499+
studies
1.00
confidence
41
Forsythia Suspensa
1.00
confidence
42
Fritillaria Cirrhosa
1.00
confidence
43
Gentiana Macrophylla
1.00
confidence
44
Ginkgo Biloba
299+
studies
1.00
confidence
45
Glycine Max
1.00
confidence
46
Glycyrrhiza Uralensis
1.00
confidence
47
Inula Japonica
1.00
confidence
48
Ligusticum Chuanxiong
1.00
confidence
49
Lilium Lancifolium
1.00
confidence
50
Litchi Chinensis
1.00
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for TOP1 (DNA topoisomerase I). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: TOP1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.