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BiohacksAI/Targets/TOP1
MOLECULAR TARGETUniProt: P11387

TOP1

DNA topoisomerase I

137 compounds · BiohacksAI corpus v20260307-01

137
compounds
Compounds
137
Gene Symbol
TOP1
NCBI Gene
7150

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About TOP1

TOP1 (DNA topoisomerase I) is a biological target studied in biomedical research. The BiohacksAI corpus identifies 137 compounds with documented interactions with this target, based on BindingDB assay data and PubMed literature.

View TOP1 on UniProt →
Compounds Targeting TOP1 (50)
1
Camptothecin
300
studies
4.93
confidence
2
Amsacrine
4.82
confidence
3
Norharmane
3.76
confidence
4
Stallimycin
3.33
confidence
5
Topotecan
300
studies
3.26
confidence
6
Hoechst 33258
3.09
confidence
7
Hymenialdisine
3.00
confidence
8
Corilagin
2.89
confidence
9
Acetylshikonin
2.48
confidence
10
Ungeremine
2.20
confidence
11
Isobutylshikonin
2.08
confidence
12
Irinotecan
298
studies
1.79
confidence
13
Ethidium Bromide
300
studies
1.61
confidence
14
Luteolin
150
studies
1.10
confidence
15
Juglone
279
studies
1.10
confidence
16
Achyranthes Bidentata
1.00
confidence
17
Agastache Rugosa
1.00
confidence
18
Allium Sativum
500
studies
1.00
confidence
19
Aloe Vera
1.00
confidence
20
Arctium Lappa
1.00
confidence
21
Artemisia Annua
1.00
confidence
22
Artemisia Argyi
1.00
confidence
23
Artemisia Capillaris
1.00
confidence
24
Aster Tataricus
1.00
confidence
25
Atractylodes Macrocephala
1.00
confidence
26
Bletilla Striata
1.00
confidence
27
Centella Asiatica
499
studies
1.00
confidence
28
Chaenomeles Speciosa
1.00
confidence
29
Cimicifuga Heracleifolia
1.00
confidence
30
Citrus Reticulata
1.00
confidence
31
Cnidium Monnieri
1.00
confidence
32
Crataegus Pinnatifida
1.00
confidence
33
Curculigo Orchioides
116
studies
1.00
confidence
34
Curcuma Longa
500
studies
1.00
confidence
35
Cuscuta Chinensis
1.00
confidence
36
Cynomorium Songaricum
1.00
confidence
37
Ephedra Sinica
1.00
confidence
38
Eriobotrya Japonica
1.00
confidence
39
Eucommia Ulmoides
1.00
confidence
40
Foeniculum Vulgare
499
studies
1.00
confidence
41
Forsythia Suspensa
1.00
confidence
42
Fritillaria Cirrhosa
1.00
confidence
43
Gentiana Macrophylla
1.00
confidence
44
Ginkgo Biloba
299
studies
1.00
confidence
45
Glycine Max
1.00
confidence
46
Glycyrrhiza Uralensis
1.00
confidence
47
Inula Japonica
1.00
confidence
48
Ligusticum Chuanxiong
1.00
confidence
49
Lilium Lancifolium
1.00
confidence
50
Litchi Chinensis
1.00
confidence
Top 50 compounds by confidence score. Derived from BindingDB assay data.
Data Source
Corpusv20260307-01
SourceBindingDB · ChEMBL · PubMed

All data is computationally derived from published research. Not medical advice. Independent validation required.