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BiohacksAI/Targets/TP53/Compounds

Compounds That Target TP53

tumor protein p53 · 276 compounds in BiohacksAI corpus

TP53 (tumor protein p53) is the most frequently mutated gene in human cancer and functions as a critical regulator of cell cycle arrest, DNA repair, and apoptosis. It acts as a transcription factor that responds to cellular stress, DNA damage, and oncogenic signals. The 276 compounds with documented TP53 interactions include both p53 activators relevant to cancer biology and natural compounds studied for their chemopreventive properties.

View TP53 target page →UniProt: P04637 ↗
Most Studied Compounds for TP53
1
Ethidium Bromide
300+
studies
2
Ethinyl Estradiol
300+
studies
3
Hexachlorophene
300+
studies
4
Bortezomib
300+
studies
5
Rotenone
300+
studies
6
Azathioprine
300+
studies
7
Apigenin
300+
studies
8
Tannic Acid
300+
studies
9
Emodin
300+
studies
10
Melphalan
300+
studies
All 50 Compounds — Ranked by Evidence
1
Nutlin 3
4.42
confidence
2
Ethidium Bromide
300+
studies
2.77
confidence
3
Ethinyl Estradiol
300+
studies
2.71
confidence
4
Hexachlorophene
300+
studies
2.71
confidence
5
Azacitidine
298+
studies
2.56
confidence
6
Azacytidine
298+
studies
2.56
confidence
7
Methylene Blue
200+
studies
2.48
confidence
8
Bortezomib
300+
studies
2.40
confidence
9
Rotenone
300+
studies
2.40
confidence
10
Azathioprine
300+
studies
2.30
confidence
11
Cladribinenucleotide
2.30
confidence
12
Apigenin
300+
studies
2.20
confidence
13
Tannic Acid
300+
studies
2.20
confidence
14
Cytarabine
297+
studies
2.20
confidence
15
Emodin
300+
studies
2.20
confidence
16
Melphalan
300+
studies
2.20
confidence
17
Niclosamideorganic
2.20
confidence
18
Potassium Dichromate
300+
studies
2.20
confidence
19
Ischemin
2.20
confidence
20
Amethopterin
289+
studies
2.08
confidence
21
Dactinomycin
297+
studies
2.08
confidence
22
Daunorubicin
298+
studies
2.08
confidence
23
Disulfiram
297+
studies
2.08
confidence
24
Glutaral
42+
studies
2.08
confidence
25
Menadione
300+
studies
2.08
confidence
26
Trifluridine
295+
studies
2.08
confidence
27
Quercetin
300+
studies
1.95
confidence
28
Axitinib
298+
studies
1.95
confidence
29
Ninhydrinpolycyclic
1.95
confidence
30
O Phthalaldehyde
300+
studies
1.95
confidence
31
Razoxane
154+
studies
1.95
confidence
32
Zearalenone
300+
studies
1.95
confidence
33
Plumbagin
300+
studies
1.79
confidence
34
Camptothecin
300+
studies
1.79
confidence
35
Reserpine
297+
studies
1.79
confidence
36
Genistein
300+
studies
1.61
confidence
37
Resveratrol
298+
studies
1.61
confidence
38
Ciclopirox Olaminedrugage
1.61
confidence
39
Clofarabinenucleotide
1.61
confidence
40
Cycloheximide
300+
studies
1.61
confidence
41
Daph
2+
studies
1.61
confidence
42
Dinitrochlorobenzene
300+
studies
1.61
confidence
43
Estramustine
300+
studies
1.61
confidence
44
Ims2186
1+
studies
1.61
confidence
45
Loratadine
296+
studies
1.61
confidence
46
Mycophenolic Aciddrugage
1.61
confidence
47
Riluzole
298+
studies
1.61
confidence
48
Thioinosine
242+
studies
1.61
confidence
49
Trabectedin
297+
studies
1.61
confidence
50
Vorinostat
299+
studies
1.61
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for TP53 (tumor protein p53). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: TP53 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.