◉Domain Discovery

Inflammation & Immune Modulation

Targets controlling inflammatory pathways and immune response. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:TNFIL6IL1BNFKB1RELAPTGS2PTGS1NOS2MAPK14MAPK8NLRP3TLR4HMOX1NFE2L2STAT3

674 compounds matched · 15 targets active

Top Emerging Inflammation & Immune Modulation Compounds

#	Compound	Top Targets	Score	Studies
1	Centella⚡	TLR4 · HMOX1 · STAT3	73.894	199
2	Foeniculum⚡	TLR4 · HMOX1 · STAT3	73.894	199
3	Piper nigrum⚡	TLR4 · HMOX1 · STAT3	73.894	199
4	Rubia⚡	TLR4 · HMOX1 · STAT3	73.825	200
5	Syzygium⚡	TLR4 · HMOX1 · STAT3	73.825	200
6	curculigo orchioides⚡	TLR4 · HMOX1 · STAT3	69.277	116
7	Portulaca⚡	TLR4 · HMOX1 · STAT3	68.025	200
8	Nelumbo⚡	TLR4 · HMOX1 · STAT3	61.521	200
9	stemona sessilifolia	TLR4 · HMOX1 · STAT3	17.956	26
10	lobelia chinensis	TLR4 · HMOX1 · STAT3	17.633	38

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Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	Centella⚡ 15% human	TLR4HMOX1STAT3NLRP3+9	73.894	199	31.6
2	Foeniculum⚡ 13% human	TLR4HMOX1STAT3NLRP3+9	73.894	199	32
3	Piper nigrum⚡ 7% human	TLR4HMOX1STAT3NLRP3+9	73.894	199	29.6
4	Rubia⚡ 6% human	TLR4HMOX1STAT3NLRP3+9	73.825	200	29.8
5	Syzygium⚡ 10% human	TLR4HMOX1STAT3NLRP3+9	73.825	200	30.6
6	curculigo orchioides⚡ 2% human	TLR4HMOX1STAT3NLRP3+7	69.277	116	28.7
7	Portulaca⚡ 9% human	TLR4HMOX1STAT3NLRP3+8	68.025	200	30.7
8	Nelumbo⚡ 6% human	TLR4HMOX1STAT3NLRP3+9	61.521	200	31.1
9	stemona sessilifolia	TLR4HMOX1STAT3NLRP3+8	17.956	26	28.7
10	lobelia chinensis 8% human	TLR4HMOX1STAT3NLRP3+9	17.633	38	25.6
11	mosla chinensis	TLR4HMOX1STAT3NLRP3+9	17.633	38	29
12	eupatorium fortunei 4% human	TLR4HMOX1STAT3TNF+8	17.559	28	23.7
13	taxillus chinensis 14% human	TLR4HMOX1STAT3TNF+8	17.397	29	29.2
14	cimicifuga heracleifolia 6% human	TLR4HMOX1STAT3NLRP3+8	16.489	36	24.9
15	mylabris phalerata 5% human	TLR4HMOX1STAT3NLRP3+8	16.375	37	24.3
16	quisqualis indica 7% human	TLR4HMOX1STAT3NLRP3+7	16.261	27	24.8
17	hirudo nipponia 2% human	TLR4HMOX1STAT3TNF+8	15.919	41	32.4
18	sb 203580	MAPK8MAPK14PTGS1	15.894	0	—
19	lycopus lucidus 7% human	TLR4HMOX1NLRP3TNF+8	15.731	43	27.2
20	alisma plantago 5% human	TLR4HMOX1STAT3NLRP3+9	15.673	62	33.3
21	vigna umbellata	TLR4HMOX1STAT3NLRP3+9	15.059	74	29.3
22	mentha haplocalyx 4% human	TLR4HMOX1STAT3NLRP3+9	14.885	78	32.9
23	asparagus cochinchinensis 1% human	TLR4HMOX1STAT3NLRP3+9	14.885	78	27.9
24	aster tataricus	TLR4HMOX1STAT3NLRP3+9	14.395	91	28
25	chaenomeles speciosa 4% human	TLR4HMOX1STAT3NLRP3+9	14.361	92	33.3

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Inflammation & Immune Modulation Compound Discovery

Discover emerging anti-inflammatory compounds via TNF, IL-6, COX-2, NF-κB, and NLRP3 inflammasome target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with inflammation & immune modulation targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: TNF, IL6, IL1B, NFKB1, RELA, PTGS2. The analysis covers 674 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.