◉Domain Discovery

Inflammation & Immune Modulation

Targets controlling inflammatory pathways and immune response. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:TNFIL6IL1BNFKB1RELAPTGS2PTGS1NOS2MAPK14MAPK8NLRP3TLR4HMOX1NFE2L2STAT3

349 compounds matched · 15 targets active

Top Emerging Inflammation & Immune Modulation Compounds

#	Compound	Top Targets	Score	Studies
1	egcgcap⚡	MAPK14 · NFKB1	10.077	300
2	Rutincap⚡	RELA · NFKB1	9.489	300
3	Quercetincap	MAPK14 · RELA · NFKB1	7.188	300
4	fisetin⚡	MAPK14	7.181	78
5	Argininecap⚡	NOS2	6.247	300
6	tyrphostin 9	NLRP3 · IL1B	5.481	2
7	tyrphostin ag 1478	MAPK14 · NFKB1	5.037	4
8	Cathelicidins Antimicrobial cationic peptides withcap⚡	RELA	4.932	300
9	tamarixetin	TLR4 · RELA · NFKB1	4.669	26
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	RELA · NFKB1 · NFE2L2	4.561	150

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Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	egcgcap⚡ 1% human	MAPK14NFKB1	10.077	300	43.2
2	Rutincap⚡ 2% human	RELANFKB1	9.489	300	41.5
3	Quercetincap 1% human	MAPK14RELANFKB1PTGS2+1	7.188	300	43.4
4	fisetin⚡	MAPK14	7.181	78	42.5
5	Argininecap⚡ 5% human	NOS2	6.247	300	49.1
6	tyrphostin 9	NLRP3IL1B	5.481	2	11.5
7	tyrphostin ag 1478	MAPK14NFKB1	5.037	4	17.2
8	Cathelicidins Antimicrobial cationic peptides withcap⚡ 1% human	RELA	4.932	300	43.1
9	tamarixetin	TLR4RELANFKB1	4.669	26	36.4
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone, 1% human	RELANFKB1NFE2L2	4.561	150	40.6
11	Podophyllotoxin 14% human	RELANFKB1NFE2L2	4.071	14	43.3
12	Kaempferolscap	RELANFKB1NFE2L2	4.014	300	43.3
13	Celecoxib 5% human	STAT3MAPK14PTGS2PTGS1+1	3.780	295	46.7
14	Budesonidecap⚡ 35% human	IL1BNFE2L2	3.612	1,000	75.3
15	Anisomycin 0% human	MAPK8MAPK14NLRP3IL1B	3.570	247	42.5
16	Vitamin K 2cap⚡ 5% human	PTGS1	3.567	300	45.1
17	Apigenin 5,7,4'-trihydroxy-flavone,cap	RELANFKB1IL1BPTGS2+1	3.341	300	42.3
18	tyrphostin 1	NFKB1	3.304	1	4.9
19	Resveratrol 1% human	RELANFKB1PTGS2PTGS1+1	3.272	298	43.7
20	Niclosamide 2% human	STAT3NLRP3IL1BNFE2L2	3.079	299	44.1
21	Bortezomibcap 10% human	RELANLRP3NFKB1NFE2L2	2.829	300	44.2
22	daph	NFKB1	2.797	2	11.3
23	Arachidonic Acid⚡ 8% human	PTGS2	2.764	245	47.4
24	Disulfiram 1% human	NLRP3NFKB1IL1BNFE2L2	2.679	297	41.3
25	propyl gallate⚡ 0% human	NFE2L2	2.617	261	42.3

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Inflammation & Immune Modulation Compound Discovery

Discover emerging anti-inflammatory compounds via TNF, IL-6, COX-2, NF-κB, and NLRP3 inflammasome target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with inflammation & immune modulation targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: TNF, IL6, IL1B, NFKB1, RELA, PTGS2. The analysis covers 349 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.