BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
BiohacksAI is an evolving scientific literature platform. New compounds and evidence are indexed continuously.
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⟳Domain Discovery

Longevity & Lifespan

Targets central to aging biology, senescence, and lifespan extension. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:SIRT1SIRT3MTORPRKAA1PRKAA2FOXO3IGF1RNFE2L2TP53TERTPTENAKT1MAPK1PPARGC1A
596 compounds matched · 14 targets active

Top Emerging Longevity & Lifespan Compounds

#CompoundTop TargetsScoreStudies
1Syzygium⚡AKT1 · IGF1R · FOXO381.999200
2Centella⚡IGF1R · FOXO3 · PPARGC1A75.249199
3Piper nigrum⚡IGF1R · FOXO3 · PPARGC1A75.249199
4Portulaca⚡IGF1R · FOXO3 · PPARGC1A75.179200
5curculigo orchioides⚡FOXO3 · PPARGC1A · PTEN70.098116
6Foeniculum⚡FOXO3 · PPARGC1A · PTEN69.138199
7Rubia⚡FOXO3 · PPARGC1A · PTEN69.074200
8Nelumbo⚡IGF1R · FOXO3 · PPARGC1A62.649200
9lestaurtinibAKT1 · IGF1R · PRKAA221.7770
10tae 684IGF1R · PRKAA2 · PRKAA120.7010
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50 compounds
#CompoundTargetsScoreStudiesEvid.
1
10% human
AKT1IGF1RFOXO3PPARGC1A+10
81.999
20030.6
2
15% human
IGF1RFOXO3PPARGC1APTEN+9
75.249
19931.6
3
7% human
IGF1RFOXO3PPARGC1APTEN+9
75.249
19929.6
4
9% human
IGF1RFOXO3PPARGC1APTEN+9
75.179
20030.7
5
2% human
FOXO3PPARGC1APTENSIRT3+7
70.098
11628.7
6
13% human
FOXO3PPARGC1APTENSIRT3+8
69.138
19932
7
6% human
FOXO3PPARGC1APTENSIRT3+8
69.074
20029.8
8
6% human
IGF1RFOXO3PPARGC1APTEN+9
62.649
20031.1
9
AKT1IGF1RPRKAA2PRKAA1
21.777
0—
10
IGF1RPRKAA2PRKAA1MAPK1
20.701
0—
11
7% human
IGF1RFOXO3PPARGC1APTEN+9
19.623
2724.8
12
FOXO3PPARGC1APTENSIRT3+8
18.213
2628.7
13
8% human
IGF1RFOXO3PPARGC1APTEN+9
17.956
3825.6
14
IGF1RFOXO3PPARGC1APTEN+9
17.956
3829
15
AKT1IGF1RFOXO3PPARGC1A+10
16.726
7429.3
16
AKT1PRKAA2PRKAA1
16.372
0—
17
4% human
FOXO3PPARGC1APTENSIRT3+7
16.294
2823.7
18
6% human
AKT1IGF1RFOXO3PPARGC1A+10
16.065
8932.9
19
IGF1RPRKAA2PRKAA1
15.739
0—
20
IGF1RPRKAA2PRKAA1
15.739
0—
21
IGF1RPRKAA2PRKAA1
15.739
0—
22
IGF1RPRKAA2PRKAA1
15.739
0—
23
IGF1RPRKAA2PRKAA1
15.739
0—
24
IGF1RPRKAA2PRKAA1
15.739
0—
25
IGF1RPRKAA2PRKAA1
15.739
0—
score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Longevity & Lifespan Compound Discovery

Discover emerging longevity compounds ranked by molecular target network analysis. SIRT1, mTOR, FOXO3, AMPK, NRF2 pathway substances ranked by research momentum and rarity. The discovery score combines three signals: target influence (how strongly a substance interacts with longevity & lifespan targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: SIRT1, SIRT3, MTOR, PRKAA1, PRKAA2, FOXO3. The analysis covers 596 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.