⟳Domain Discovery

Longevity & Lifespan

Targets central to aging biology, senescence, and lifespan extension. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:SIRT1SIRT3MTORPRKAA1PRKAA2FOXO3IGF1RNFE2L2TP53TERTAKT1MAPK1

313 compounds matched · 12 targets active

Top Emerging Longevity & Lifespan Compounds

#	Compound	Top Targets	Score	Studies
1	egcgcap⚡	TERT · MTOR	11.341	300
2	Berberinecap⚡	PRKAA1 · PRKAA2	11.046	300
3	Quercetincap	IGF1R · AKT1 · PRKAA2	8.065	300
4	ly294002	FOXO3 · IGF1R · MTOR	7.743	11
5	fisetin⚡	MAPK1	6.353	78
6	Rutincap⚡	PRKAA2	5.436	300
7	chrysincap⚡	TP53 · NFE2L2	5.414	300
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).cap⚡	TP53 · NFE2L2	5.414	300
9	daph	MAPK1 · TP53	4.752	2
10	tyrphostin 9	MTOR · TP53	4.620	2

Sort

Min targets

Target

Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	egcgcap⚡ 1% human	TERTMTOR	11.341	300	43.2
2	Berberinecap⚡ 7% human	PRKAA1PRKAA2	11.046	300	47.9
3	Quercetincap 1% human	IGF1RAKT1PRKAA2TP53+1	8.065	300	43.4
4	ly294002	FOXO3IGF1RMTORNFE2L2	7.743	11	29.6
5	fisetin⚡	MAPK1	6.353	78	42.5
6	Rutincap⚡ 2% human	PRKAA2	5.436	300	41.5
7	chrysincap⚡ 0% human	TP53NFE2L2	5.414	300	39.8
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).cap⚡	TP53NFE2L2	5.414	300	42.6
9	daph	MAPK1TP53	4.752	2	11.3
10	tyrphostin 9	MTORTP53	4.620	2	11.5
11	pd98059	MAPK1TP53NFE2L2	4.311	7	20.8
12	Puerariacap⚡ 1% human	TP53NFE2L2	3.609	300	43.4
13	trequinsin hydrochloride	MAPK1	3.540	1	7.6
14	Niclosamide 2% human	PRKAA1PRKAA2MTORTP53+1	3.523	299	44.1
15	Rotenonecap	PRKAA1PRKAA2MTORTP53+1	3.521	300	36
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone, 1% human	AKT1NFE2L2	3.494	150	40.6
17	Resveratrol 1% human	SIRT1FOXO3TP53NFE2L2	3.373	298	43.7
18	Ku 0063794 [Supplementary Concept]	MTORTP53	3.152	7	24.5
19	Metformincap 49% human	PRKAA1PRKAA2	3.044	1,000	71.9
20	Antimycincap	PRKAA1PRKAA2TP53NFE2L2	2.743	300	42
21	clofilium tosylate	TP53NFE2L2	2.706	4	22.3
22	Kaempferolscap	PRKAA2NFE2L2	2.663	300	43.3
23	Ursolic Acidcap	PRKAA1PRKAA2MTOR	2.619	300	42.3
24	propyl gallate⚡ 0% human	NFE2L2	2.617	261	42.3
25	Suramincap 5% human	SIRT3SIRT1	2.588	300	42.2

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Longevity & Lifespan Compound Discovery

Discover emerging longevity compounds ranked by molecular target network analysis. SIRT1, mTOR, FOXO3, AMPK, NRF2 pathway substances ranked by research momentum and rarity. The discovery score combines three signals: target influence (how strongly a substance interacts with longevity & lifespan targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: SIRT1, SIRT3, MTOR, PRKAA1, PRKAA2, FOXO3. The analysis covers 313 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.