Targets regulating glucose metabolism, insulin sensitivity, and lipid balance. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.
| # | Compound | Top Targets | Score | Studies |
|---|---|---|---|---|
| 1 | curculigo orchioides⚡ | HNF4A · LEP · IRS1 | 83.138 | 116 |
| 2 | Syzygium⚡ | AKT1 · HNF4A · LEP | 81.583 | 200 |
| 3 | Centella⚡ | HNF4A · LEP · IRS1 | 74.833 | 199 |
| 4 | Foeniculum⚡ | HNF4A · LEP · IRS1 | 74.833 | 199 |
| 5 | Piper nigrum⚡ | HNF4A · LEP · IRS1 | 74.833 | 199 |
| 6 | Portulaca⚡ | HNF4A · LEP · IRS1 | 74.763 | 200 |
| 7 | Rubia⚡ | HNF4A · LEP · IRS1 | 74.763 | 200 |
| 8 | Nelumbo⚡ | HNF4A · LEP · IRS1 | 62.303 | 200 |
| 9 | lestaurtinib | AKT1 · PRKAA2 · INSR | 26.533 | 0 |
| 10 | midostaurin | AKT1 · PRKAA2 · PRKAA1 | 21.398 | 0 |
| # | Compound | Targets | Score | Studies | Evid. |
|---|---|---|---|---|---|
| 1 | 2% human | HNF4ALEPIRS1LEPR+9 | 83.138 | 116 | 28.7 |
| 2 | 10% human | AKT1HNF4ALEPIRS1+10 | 81.583 | 200 | 30.6 |
| 3 | 15% human | HNF4ALEPIRS1LEPR+9 | 74.833 | 199 | 31.6 |
| 4 | 13% human | HNF4ALEPIRS1LEPR+9 | 74.833 | 199 | 32 |
| 5 | 7% human | HNF4ALEPIRS1LEPR+9 | 74.833 | 199 | 29.6 |
| 6 | 9% human | HNF4ALEPIRS1LEPR+9 | 74.763 | 200 | 30.7 |
| 7 | 6% human | HNF4ALEPIRS1LEPR+9 | 74.763 | 200 | 29.8 |
| 8 | 6% human | HNF4ALEPIRS1LEPR+9 | 62.303 | 200 | 31.1 |
| 9 | AKT1PRKAA2INSRPRKAA1+1 | 26.533 | 0 | — | |
| 10 | AKT1PRKAA2PRKAA1PIK3CA | 21.398 | 0 | — | |
| 11 | PRKAA2INSRPRKAA1PIK3CA | 20.495 | 0 | — | |
| 12 | 7% human | HNF4ALEPIRS1LEPR+9 | 19.514 | 27 | 24.8 |
| 13 | 8% human | HNF4ALEPIRS1LEPR+9 | 17.856 | 38 | 25.6 |
| 14 | HNF4ALEPIRS1LEPR+9 | 17.856 | 38 | 29 | |
| 15 | 4% human | LEPIRS1LEPRSLC2A4+8 | 17.742 | 28 | 23.7 |
| 16 | 6% human | HNF4ALEPIRS1LEPR+8 | 16.960 | 36 | 24.9 |
| 17 | AKT1HNF4ALEPIRS1+10 | 16.641 | 74 | 29.3 | |
| 18 | 5% human | LEPIRS1LEPRSLC2A4+8 | 16.504 | 37 | 24.3 |
| 19 | 6% human | AKT1HNF4ALEPIRS1+10 | 15.984 | 89 | 32.9 |
| 20 | 7% human | LEPIRS1LEPRSLC2A4+8 | 15.897 | 43 | 27.2 |
| 21 | 5% human | HNF4ALEPIRS1LEPR+9 | 15.872 | 62 | 33.3 |
| 22 | 6% human | HNF4ALEPIRS1LEPR+9 | 15.702 | 65 | 27.8 |
| 23 | PRKAA2INSRPRKAA1 | 15.469 | 0 | — | |
| 24 | PRKAA2INSRPRKAA1 | 15.469 | 0 | — | |
| 25 | PRKAA2INSRPRKAA1 | 15.469 | 0 | — |
Discover emerging metabolic health compounds via AMPK, PPAR-gamma, insulin receptor, and AKT1 target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with metabolic health & glucose targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.
Key targets in this domain include: INSR, IRS1, PIK3CA, AKT1, PRKAA1, PRKAA2. The analysis covers 606 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.