◆Domain Discovery

Metabolic Health & Glucose

Targets regulating glucose metabolism, insulin sensitivity, and lipid balance. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:INSRPIK3CAAKT1PRKAA1PRKAA2PPARGPPARAPPARDSLC2A4NR1I2HNF4A

323 compounds matched · 11 targets active

Top Emerging Metabolic Health & Glucose Compounds

#	Compound	Top Targets	Score	Studies
1	Berberinecap⚡	PRKAA1 · PRKAA2 · PPARA	16.140	300
2	Arachidonic Acid⚡	PPARA · PPARD · PPARG	8.946	245
3	Rutincap⚡	PRKAA2 · PPARG	8.924	300
4	Quercetincap	AKT1 · PRKAA2 · PPARG	5.963	300
5	chrysincap⚡	PPARG · NR1I2	5.782	300
6	trequinsin hydrochloride	PPARG · NR1I2	4.192	1
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	AKT1 · PPARG	3.848	150
8	Kaempferolscap	PRKAA2 · PPARG · NR1I2	3.739	300
9	Linoleic Acidcap	HNF4A · PPARA · PPARD	3.531	300
10	Rotenonecap	PRKAA1 · PRKAA2 · PPARD	3.150	300

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Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	Berberinecap⚡ 7% human	PRKAA1PRKAA2PPARA	16.140	300	47.9
2	Arachidonic Acid⚡ 8% human	PPARAPPARDPPARG	8.946	245	47.4
3	Rutincap⚡ 2% human	PRKAA2PPARG	8.924	300	41.5
4	Quercetincap 1% human	AKT1PRKAA2PPARGNR1I2	5.963	300	43.4
5	chrysincap⚡ 0% human	PPARGNR1I2	5.782	300	39.8
6	trequinsin hydrochloride	PPARGNR1I2	4.192	1	7.6
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone, 1% human	AKT1PPARG	3.848	150	40.6
8	Kaempferolscap	PRKAA2PPARGNR1I2	3.739	300	43.3
9	Linoleic Acidcap 1% human	HNF4APPARAPPARDPPARG+1	3.531	300	43.7
10	Rotenonecap	PRKAA1PRKAA2PPARDPPARG	3.150	300	36
11	Metformincap 49% human	PRKAA1PRKAA2	3.044	1,000	71.9
12	Apigenin 5,7,4'-trihydroxy-flavone,cap	INSRPPARDPPARGNR1I2	2.764	300	42.3
13	Ursolic Acidcap	PRKAA1PRKAA2PPARA	2.690	300	42.3
14	Oleic Acid 7% human	PPARAPPARDPPARG	2.599	112	48.1
15	Sirolimuscap 2% human	AKT1PIK3CANR1I2	2.568	300	45.4
16	Fenofibrate 7% human	PPARAPPARDPPARGNR1I2	2.545	297	47.1
17	hydroxyfasudil [Supplementary Concept]	AKT1	2.426	11	27.5
18	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	PRKAA1PRKAA2	2.409	76	40.3
19	Crizotinib 17% human	INSRPRKAA1NR1I2	2.393	298	46.7
20	Mepentol [Supplementary Concept] 5% human	PPARAPPARDPPARG	2.357	184	44.1
21	propyl gallate⚡ 0% human	NR1I2	2.350	261	42.3
22	ly294002	PIK3CA	2.341	11	29.6
23	Dehydroepiandrosterone Sulfatecap⚡ 3% human	PPARG	2.326	300	46.8
24	Vitamin K 2cap⚡ 5% human	NR1I2	2.293	300	45.1
25	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).cap⚡	NR1I2	2.293	300	42.6

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Metabolic Health & Glucose Compound Discovery

Discover emerging metabolic health compounds via AMPK, PPAR-gamma, insulin receptor, and AKT1 target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with metabolic health & glucose targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: INSR, IRS1, PIK3CA, AKT1, PRKAA1, PRKAA2. The analysis covers 323 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.