◎Domain Discovery

Stress Resilience & Adaptogens

Targets involved in HPA axis, cortisol regulation, and stress adaptation. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.

Targets:NR3C1FKBP5NFE2L2HMOX1HSP90AA1HSPA1AMAPK14MAPK8SOD1GPX1

341 compounds matched · 10 targets active

Top Emerging Stress Resilience & Adaptogens Compounds

#	Compound	Top Targets	Score	Studies
1	Thioctic Acid⚡	GPX1 · NFE2L2	7.399	298
2	fisetin⚡	MAPK14	7.181	78
3	propyl gallate⚡	NR3C1 · NFE2L2	5.555	261
4	egcgcap⚡	MAPK14	5.519	300
5	chrysincap⚡	NR3C1 · NFE2L2	5.421	300
6	Quercetincap	MAPK14 · HSP90AA1 · NR3C1	5.166	300
7	Puerariacap⚡	NR3C1 · NFE2L2	3.614	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]cap	MAPK14 · HSP90AA1	3.359	300
9	Budesonidecap⚡	NR3C1 · NFE2L2	2.988	1,000
10	stx64	GPX1	2.968	2

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Under-cap onlyAccelerating ⚡50 compounds

#	Compound	Targets	Score	Studies	Evid.
1	Thioctic Acid⚡ 6% human	GPX1NFE2L2	7.399	298	43.8
2	fisetin⚡	MAPK14	7.181	78	42.5
3	propyl gallate⚡ 0% human	NR3C1NFE2L2	5.555	261	42.3
4	egcgcap⚡ 1% human	MAPK14	5.519	300	43.2
5	chrysincap⚡ 0% human	NR3C1NFE2L2	5.421	300	39.8
6	Quercetincap 1% human	MAPK14HSP90AA1NR3C1NFE2L2	5.166	300	43.4
7	Puerariacap⚡ 1% human	NR3C1NFE2L2	3.614	300	43.4
8	myricetin-3-O-galactopyranoside [Supplementary Concept]cap 0% human	MAPK14HSP90AA1	3.359	300	42.3
9	Budesonidecap⚡ 35% human	NR3C1NFE2L2	2.988	1,000	75.3
10	stx64	GPX1	2.968	2	9.1
11	tyrphostin ag 1478	MAPK14	2.759	4	17.2
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).cap⚡	NFE2L2	2.554	300	42.6
13	Taurinecap⚡ 2% human	NFE2L2	2.554	300	45
14	Miconazole 8% human	HMOX1HSP90AA1NR3C1	2.474	298	46.8
15	Anisomycin 0% human	MAPK8MAPK14	2.030	247	42.5
16	specioside	HSP90AA1	2.004	6	26.1
17	triolimus [Supplementary Concept] 21% human	HSP90AA1NR3C1	1.977	33	43.4
18	Tetracyclinecap 1% human	SOD1HSP90AA1	1.922	300	43.9
19	monorden	HSP90AA1	1.829	8	25.9
20	Celecoxib 5% human	MAPK14NR3C1NFE2L2	1.829	295	46.7
21	Kaempferolscap	NR3C1NFE2L2	1.807	300	43.3
22	pictilisib 32% human	MAPK8	1.791	25	46.2
23	sp600125	MAPK8NFE2L2	1.751	117	43.3
24	Everolimus 6% human	FKBP5NR3C1	1.714	297	46.2
25	Clotrimazole 9% human	HSP90AA1NR3C1NFE2L2	1.667	296	48.8

score = target_influence × rarity × momentum⚡ acceleration >2×cap = ≥300 studies (corpus ceiling)click target chip to filter

About Stress Resilience & Adaptogens Compound Discovery

Discover emerging adaptogenic and stress-resilience compounds via glucocorticoid receptor, NRF2, SOD, and heat shock protein target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with stress resilience & adaptogens targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.

Key targets in this domain include: NR3C1, CRH, POMC, FKBP5, NFE2L2, HMOX1. The analysis covers 341 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.