Targets involved in HPA axis, cortisol regulation, and stress adaptation. Compounds are ranked by target influence (IDF-weighted), research rarity, and momentum — revealing under-studied candidates with active signal.
| # | Compound | Top Targets | Score | Studies |
|---|---|---|---|---|
| 1 | Centella⚡ | CRH · HSPA1A · SOD1 | 51.770 | 199 |
| 2 | Piper nigrum⚡ | CRH · HSPA1A · SOD1 | 51.770 | 199 |
| 3 | Foeniculum⚡ | CRH · HSPA1A · SOD1 | 51.770 | 199 |
| 4 | Portulaca⚡ | CRH · HSPA1A · SOD1 | 51.722 | 200 |
| 5 | Rubia⚡ | CRH · HSPA1A · SOD1 | 51.722 | 200 |
| 6 | Syzygium⚡ | CRH · HSPA1A · SOD1 | 51.722 | 200 |
| 7 | Nelumbo⚡ | CRH · HSPA1A · SOD1 | 43.102 | 200 |
| 8 | curculigo orchioides⚡ | SOD1 · HMOX1 · CAT | 37.471 | 116 |
| 9 | molibresib | GPX1 · HSPA1A · CAT | 22.625 | 0 |
| 10 | eupatorium fortunei | CRH · HSPA1A · SOD1 | 13.370 | 28 |
| # | Compound | Targets | Score | Studies | Evid. |
|---|---|---|---|---|---|
| 1 | 15% human | CRHHSPA1ASOD1HMOX1+5 | 51.770 | 199 | 31.6 |
| 2 | 7% human | CRHHSPA1ASOD1HMOX1+5 | 51.770 | 199 | 29.6 |
| 3 | 13% human | CRHHSPA1ASOD1HMOX1+5 | 51.770 | 199 | 32 |
| 4 | 9% human | CRHHSPA1ASOD1HMOX1+5 | 51.722 | 200 | 30.7 |
| 5 | 6% human | CRHHSPA1ASOD1HMOX1+5 | 51.722 | 200 | 29.8 |
| 6 | 10% human | CRHHSPA1ASOD1HMOX1+5 | 51.722 | 200 | 30.6 |
| 7 | 6% human | CRHHSPA1ASOD1HMOX1+5 | 43.102 | 200 | 31.1 |
| 8 | 2% human | SOD1HMOX1CATHSP90AA1+2 | 37.471 | 116 | 28.7 |
| 9 | GPX1HSPA1ACATHSP90AA1 | 22.625 | 0 | — | |
| 10 | 4% human | CRHHSPA1ASOD1HMOX1+5 | 13.370 | 28 | 23.7 |
| 11 | 8% human | CRHHSPA1ASOD1HMOX1+5 | 12.353 | 38 | 25.6 |
| 12 | CRHHSPA1ASOD1HMOX1+5 | 12.353 | 38 | 29 | |
| 13 | CRHHSPA1ASOD1HMOX1+4 | 12.128 | 26 | 28.7 | |
| 14 | 2% human | CRHHSPA1ASOD1HMOX1+5 | 12.121 | 41 | 32.4 |
| 15 | 7% human | CRHHSPA1ASOD1HMOX1+4 | 12.006 | 27 | 24.8 |
| 16 | 14% human | HSPA1ASOD1HMOX1CAT+4 | 11.647 | 29 | 29.2 |
| 17 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 18 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 19 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 20 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 21 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 22 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 23 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 24 | MAPK8MAPK14 | 11.331 | 0 | — | |
| 25 | MAPK8MAPK14 | 11.331 | 0 | — |
Discover emerging adaptogenic and stress-resilience compounds via glucocorticoid receptor, NRF2, SOD, and heat shock protein target networks. The discovery score combines three signals: target influence (how strongly a substance interacts with stress resilience & adaptogens targets, weighted by target specificity via IDF), rarity factor (inverse log of study count — fewer studies means higher discovery potential), and momentum factor (recent publication acceleration). Compounds with high scores represent mechanistically relevant, under-researched candidates with active research interest.
Key targets in this domain include: NR3C1, CRH, POMC, FKBP5, NFE2L2, HMOX1. The analysis covers 575 compounds from the BiohacksAI corpus of 4,824 substances derived from PubMed-indexed bioassay data.