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BiohacksAI/Pathways/Proteostasis / UPS
PATHWAYProteostasis

Proteostasis / UPS

Protein homeostasis — chaperone-mediated folding, ubiquitin-proteasome degradation

1,282 compounds · BiohacksAI corpus

1,282
compounds
Compounds
1,282
Category
Proteostasis
Pathway ID
PROTEOSTASIS
MeSH Terms
Proteasome Endopeptidase ComplexUbiquitinHeat-Shock ProteinsChaperonesUnfolded Protein ResponseEndoplasmic Reticulum StressProtein Aggregation, Pathological
Top Compounds — Proteostasis / UPS (50 of 1,282)
1
Liraglutide
999
studies
76.7
evidence
2
Insulin
1,000
studies
70.5
evidence
3
Alpha_linolenic_acid
518
studies
55.8
evidence
4
Glycine
300
studies
54.6
evidence
5
Lysine
299
studies
51.2
evidence
6
Dha
300
studies
62.2
evidence
7
Proline
300
studies
47.2
evidence
8
Oryza_sativa
500
studies
37.0
evidence
9
Cymbopogon_citratus
500
studies
37.4
evidence
10
Neuropeptide_y
500
studies
44.2
evidence
11
Brassica_campestris
500
studies
40.0
evidence
12
Hibiscus_sabdariffa
500
studies
41.3
evidence
13
Nelumbo__nucifera
500
studies
39.5
evidence
14
Phoenix__dactylifera
500
studies
38.3
evidence
15
Phoenix_dactylifera
500
studies
38.3
evidence
16
Terminalia_chebula
500
studies
39.0
evidence
17
Galanin
500
studies
43.1
evidence
18
Prunus_avium
500
studies
42.2
evidence
19
Solanum_nigrum
500
studies
36.7
evidence
20
Withania_somnifera
500
studies
37.6
evidence
21
Riboflavin
297
studies
48.6
evidence
22
Inositol
300
studies
54.4
evidence
23
Papaver_somniferum
497
studies
41.4
evidence
24
Resveratrol
298
studies
52.2
evidence
25
L_carnitine
495
studies
62.4
evidence
26
Ergosterol
300
studies
40.3
evidence
27
Boron
300
studies
41.4
evidence
28
Glutamine
300
studies
61.8
evidence
29
Rapamycin
300
studies
55.5
evidence
30
Vitamin_b_12
488
studies
57.5
evidence
31
Celecoxib
295
studies
60.2
evidence
32
Quercetin
300
studies
48.2
evidence
33
Betaine
299
studies
48.4
evidence
34
Ellagic_acid
475
studies
40.7
evidence
35
Kaempferol
300
studies
42.5
evidence
36
Resistant_starch
471
studies
51.9
evidence
37
Apigenin
300
studies
41.4
evidence
38
Berberine
300
studies
49.2
evidence
39
Vitamin_k2
465
studies
51.3
evidence
40
Silymarin
300
studies
48.7
evidence
41
Akkermansia_muciniphila
463
studies
49.2
evidence
42
Sulforaphane
300
studies
43.7
evidence
43
Astaxanthin
300
studies
45.9
evidence
44
Canagliflozin
295
studies
58.8
evidence
45
Alpha_lipoic_acid
452
studies
53.3
evidence
46
Acetyl_l_carnitine
433
studies
51.1
evidence
47
Spermidine
241
studies
43.7
evidence
48
Citicolinenootropic
426
studies
53.9
evidence
49
Myricetinflavonoids
409
studies
40.2
evidence
50
Rosmarinic_acid
406
studies
40.7
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.