PATHWAYNAD+ / Epigenetics
Sirtuin Activation
NAD+-dependent deacetylases (SIRT1-7) — regulate gene expression, DNA repair, mitochondrial biogenesis
574 compounds · BiohacksAI corpus
574
compounds
Compounds
574
Category
NAD+ / Epigenetics
Pathway ID
SIRT
MeSH Terms
SirtuinsSirtuin 1Sirtuin 3SIRT1 ProteinSilent Information RegulatorHistone Deacetylases
Top Compounds — Sirtuin Activation (50 of 574)
996
studies
73.3
evidence
2
Allium_sativum
500
studies
39.1
evidence
3
Crocus_sativus
500
studies
40.6
evidence
4
Neuropeptide_y
500
studies
44.2
evidence
5
Psoralea_corylifolia
500
studies
37.1
evidence
6
Raphanus_sativus
500
studies
38.0
evidence
7
Syzygium_aromaticum
500
studies
37.4
evidence
8
Vitis_vinifera
500
studies
40.1
evidence
500
studies
43.1
evidence
10
Momordica_charantia
500
studies
38.6
evidence
11
Sesamum_indicum
500
studies
41.6
evidence
12
Withania_somnifera
500
studies
37.6
evidence
13
Foeniculum_vulgare
499
studies
38.5
evidence
14
Nigella_sativa
499
studies
41.7
evidence
15
Trigonella_foenum
499
studies
39.0
evidence
16
Glycyrrhiza_glabra
498
studies
37.9
evidence
17
300
studies
44.4
evidence
18
Sirtuin_3
300
studies
42.9
evidence
19
Sirtuin_1
300
studies
45.0
evidence
20
Histone_deacetylase_3
300
studies
42.9
evidence
21
Histone_deacetylases
300
studies
42.6
evidence
22
Histone_deacetylase_6
300
studies
39.1
evidence
23
Histone_deacetylase_1
300
studies
43.3
evidence
24
Nadenzyme
300
studies
43.0
evidence
25
Histone_deacetylase_2
300
studies
45.0
evidence
26
Nicotinamide_mononucleotide
300
studies
41.8
evidence
27
Nad_
300
studies
44.2
evidence
28
Nicotinamide_riboside
300
studies
42.9
evidence
29
300
studies
42.1
evidence
30
Sirtuin_2
300
studies
42.9
evidence
31
Trichostatin_a
300
studies
39.9
evidence
300
studies
40.2
evidence
300
studies
45.5
evidence
34
Piceatannoldrugage
300
studies
36.5
evidence
35
Urolithin_a
300
studies
39.9
evidence
300
studies
45.0
evidence
37
Adenosine_diphosphate_ribose
300
studies
46.3
evidence
38
Astragaloside_iv
300
studies
40.3
evidence
300
studies
37.2
evidence
300
studies
37.7
evidence
41
300
studies
39.8
evidence
42
Nicotinamide_adenine_dinucleotide
300
studies
42.7
evidence
43
Beta_hydroxybutyrate
300
studies
45.9
evidence
300
studies
37.9
evidence
300
studies
42.6
evidence
46
300
studies
37.8
evidence
47
Astragalus_polysaccharide
300
studies
38.2
evidence
48
Carnosic_acid
300
studies
36.8
evidence
300
studies
38.8
evidence
300
studies
42.7
evidence
Data from PubMed, BindingDB, and Reactome. Not medical advice.