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BiohacksAI/Pathways/Sirtuin Activation
PATHWAYNAD+ / Epigenetics

Sirtuin Activation

NAD+-dependent deacetylases (SIRT1-7) — regulate gene expression, DNA repair, mitochondrial biogenesis

574 compounds · BiohacksAI corpus

574
compounds
Compounds
574
Category
NAD+ / Epigenetics
Pathway ID
SIRT
MeSH Terms
SirtuinsSirtuin 1Sirtuin 3SIRT1 ProteinSilent Information RegulatorHistone Deacetylases
Top Compounds — Sirtuin Activation (50 of 574)
1
Empagliflozin
996
studies
73.3
evidence
2
Alpha_linolenic_acid
518
studies
55.8
evidence
3
Lysine
299
studies
51.2
evidence
4
Ribose
300
studies
54.5
evidence
5
Epa
300
studies
64.5
evidence
6
Crocus_sativus
500
studies
40.6
evidence
7
Neuropeptide_y
500
studies
44.2
evidence
8
Galanin
500
studies
43.1
evidence
9
Momordica_charantia
500
studies
38.6
evidence
10
Sesamum_indicum
500
studies
41.6
evidence
11
Withania_somnifera
500
studies
37.6
evidence
12
Nigella_sativa
499
studies
41.7
evidence
13
Trigonella_foenum
499
studies
39.0
evidence
14
Glycyrrhiza_glabra
498
studies
37.9
evidence
15
Resveratrol
298
studies
52.2
evidence
16
Ergosterol
300
studies
40.3
evidence
17
Butyrate
300
studies
56.5
evidence
18
Rapamycin
300
studies
55.5
evidence
19
Celecoxib
295
studies
60.2
evidence
20
Taurine
300
studies
46.1
evidence
21
Quercetin
300
studies
48.2
evidence
22
Chlorogenic_acid
483
studies
42.0
evidence
23
Ellagic_acid
475
studies
40.7
evidence
24
Kaempferol
300
studies
42.5
evidence
25
Apigenin
300
studies
41.4
evidence
26
Berberine
300
studies
49.2
evidence
27
Vitamin_k2
465
studies
51.3
evidence
28
Silymarin
300
studies
48.7
evidence
29
Sulforaphane
300
studies
43.7
evidence
30
Astaxanthin
300
studies
45.9
evidence
31
Canagliflozin
295
studies
58.8
evidence
32
Alpha_lipoic_acid
452
studies
53.3
evidence
33
Niacinheterocyclic
448
studies
56.2
evidence
34
Spermidine
241
studies
43.7
evidence
35
Citicolinenootropic
426
studies
53.9
evidence
36
Myricetinflavonoids
409
studies
40.2
evidence
37
Rosmarinic_acid
406
studies
40.7
evidence
38
Cordyceps
279
studies
43.3
evidence
39
Nicotinamide_riboside
354
studies
44.7
evidence
40
Pterostilbene
299
studies
39.6
evidence
41
Alpha_ketoglutarate
354
studies
46.2
evidence
42
L_theanine
352
studies
45.9
evidence
43
Nicotinamide_mononucleotide
347
studies
43.6
evidence
44
Vinpocetine
299
studies
44.3
evidence
45
Luteolin
150
studies
44.5
evidence
46
Urolithin_a
337
studies
41.1
evidence
47
Ergothioneine
300
studies
43.3
evidence
48
Pyrroloquinoline_quinone
310
studies
38.7
evidence
49
Sirtuins
300
studies
44.4
evidence
50
Sirtuin_3
300
studies
42.9
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.