What compounds affect the PKA-mediated phosphorylation of CREB pathway?

60 compounds in the BiohacksAI corpus have documented interactions with genes in the PKA-mediated phosphorylation of CREB pathway (Reactome ID: R-HSA-111931). These compounds target 6 genes within this pathway.

What genes are in the PKA-mediated phosphorylation of CREB pathway?

The PKA-mediated phosphorylation of CREB pathway involves 6 genes. Key genes include: ADCY9, CREB1, PRKACA, PRKACB, PRKACG, PRKX.

PKA-mediated phosphorylation of CREB

REACTOME PATHWAY

Reactome: R-HSA-1119316 genes60 compounds

The PKA-mediated phosphorylation of CREB pathway (Reactome ID: R-HSA-111931) involves 6 genes and is affected by 60 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CREB1 PRKACA PRKACB PRKACG PRKX

Compounds Affecting PKA-mediated phosphorylation of CREB

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Disulfiram	—	297
3	cycloheximide	—	300
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Levalbuterol	—	1,000
8	Adenosine Monophosphate Adenine nucleotide containing	—	300
9	Levalbuterol	—	297
10	Bortezomib	—	300
11	Clofarabine	—	298
12	Dactinomycin	—	297
13	Danazol	—	298
14	Emetine	—	298
15	Ethidium	—	300
16	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
17	Sulbactam	—	299
18	trequinsin hydrochloride	—	1
19	chrysin	—	300
20	Genistein	—	300
21	Quercetin	—	300
22	Testosterone	—	299
23	Ciclopirox	—	88
24	Cladribine	—	297
25	Clenbuterol	—	300
26	Corticosterone	—	300
27	Dasatinib	—	299
28	Daunorubicin	—	298
29	Dinoprostone	—	296
30	Epinephrine	—	299
31	Ethinyl Estradiol	—	300
32	Imatinib Mesylate	—	300
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Nisoldipine	—	297
35	Nocodazole Nocodazole is	—	215
36	Masoprocol	—	300
37	Norepinephrine Precursor of epinephrine that is secreted by	—	298
38	o-Phthalaldehyde	—	300
39	Oxyphenbutazone	—	300
40	pivampicillin	—	275
41	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
42	Salmeterol Xinafoate	—	227
43	Tilorone	—	300
44	Urea	—	297
45	Carmustine	—	297
46	Edaravone	—	298
47	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
48	Iodoacetamide	—	300
49	Cisplatin	—	300
50	Cilostazol	—	297

About the PKA-mediated phosphorylation of CREB Pathway

The PKA-mediated phosphorylation of CREB pathway is catalogued in Reactome (ID: R-HSA-111931) and involves 6 genes. In the BiohacksAI corpus, 60 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CREB1, PRKACA, PRKACB, PRKACG.