Activation of PUMA and translocation to mitochondria

Q: What compounds affect the Activation of PUMA and translocation to mitochondria pathway?

151 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of PUMA and translocation to mitochondria pathway (Reactome ID: R-HSA-139915). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1399151 genes151 compounds

The Activation of PUMA and translocation to mitochondria pathway (Reactome ID: R-HSA-139915) involves 1 genes and is affected by 151 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

TP53

Compounds Affecting Activation of PUMA and translocation to mitochondria

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Ethinyl Estradiol	—	300
3	Hexachlorophene	—	300
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Methylene Blue	—	200
7	Bortezomib	—	300
8	Rotenone	—	300
9	Azathioprine	—	300
10	Cladribine	—	297
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
13	Cytarabine	—	297
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	Melphalan	—	300
16	Niclosamide	—	299
17	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
18	Methotrexate	—	289
19	Dactinomycin	—	297
20	Daunorubicin	—	298
21	Disulfiram	—	297
22	Glutaral	—	42
23	Vitamin K 3	—	300
24	Trifluridine	—	295
25	Quercetin	—	300
26	Axitinib	—	298
27	ninhydrin	—	300
28	o-Phthalaldehyde	—	300
29	Razoxane	—	154
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
31	plumbagin [Supplementary Concept]	—	300
32	Camptothecin	—	300
33	Reserpine	—	297
34	Genistein	—	300
35	Resveratrol	—	298
36	Ciclopirox	—	88
37	Clofarabine	—	298
38	cycloheximide	—	300
39	daph	—	2
40	Dinitrochlorobenzene	—	300
41	Estramustine	—	300
42	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
43	Loratadine	—	296
44	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
45	Riluzole	—	298
46	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
47	Trabectedin	—	297
48	Vorinostat	—	299
49	Clotrimazole	—	296
50	Demeclocycline	—	5

About the Activation of PUMA and translocation to mitochondria Pathway

The Activation of PUMA and translocation to mitochondria pathway is catalogued in Reactome (ID: R-HSA-139915) and involves 1 genes. In the BiohacksAI corpus, 151 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include TP53.