What compounds affect the Reproduction pathway?

67 compounds in the BiohacksAI corpus have documented interactions with genes in the Reproduction pathway (Reactome ID: R-HSA-1474165). These compounds target 12 genes within this pathway.

What genes are in the Reproduction pathway?

The Reproduction pathway involves 12 genes. Key genes include: ATM, BLM, BRCA1, CATSPER1, CATSPER2, CATSPER4, CDK2, CDK4, KCNU1, LMNA.

Reproduction

REACTOME PATHWAY

Reactome: R-HSA-147416512 genes67 compounds

The Reproduction pathway (Reactome ID: R-HSA-1474165) involves 12 genes and is affected by 67 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BLM BRCA1 CATSPER1 CATSPER2 CATSPER4 CDK2 CDK4 KCNU1 LMNA RAD51 RBBP8

Compounds Affecting Reproduction

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Alprostadil	—	297
3	Dinoprostone	—	296
4	Aurintricarboxylic Acid	—	184
5	Methylene Blue	—	200
6	streptonigrin	—	299
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Resveratrol	—	298
9	Methotrexate	—	289
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Calcimycin	—	216
14	calycosin	—	300
15	Chlorhexidine	—	299
16	Ciclopirox	—	88
17	Colchicine	—	300
18	colchine	—	2
19	cycloheximide	—	300
20	Cytarabine	—	297
21	Demecolcine	—	246
22	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
23	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
24	dihydrorotenone	—	13
25	Fluspirilene	—	74
26	gedunin	—	54
27	Hexachlorophene	—	300
28	lidoflazine	—	278
29	Melphalan	—	300
30	Niclosamide	—	299
31	Nocodazole Nocodazole is	—	215
32	paxilline	—	42
33	Podophyllotoxin	—	14
34	rafoxanide	—	172
35	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
36	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
37	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
38	Trifluridine	—	295
39	Tubercidin	—	300
40	vinblastine sulfate	—	81
41	Daunorubicin	—	298
42	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
43	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
44	Quercetin	—	300
45	Estramustine	—	300
46	Idarubicin	—	299
47	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
48	DEAD-box RNA Helicases	—	169
49	Thioctic Acid	—	298
50	Rosmarinic Acid	—	300

About the Reproduction Pathway

The Reproduction pathway is catalogued in Reactome (ID: R-HSA-1474165) and involves 12 genes. In the BiohacksAI corpus, 67 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BLM, BRCA1, CATSPER1, CATSPER2.