What compounds affect the PI Metabolism pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the PI Metabolism pathway (Reactome ID: R-HSA-1483255). These compounds target 20 genes within this pathway.

What genes are in the PI Metabolism pathway?

The PI Metabolism pathway involves 20 genes. Key genes include: BMX, INPPL1, PI4K2A, PI4K2B, PI4KA, PI4KB, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3.

PI Metabolism

REACTOME PATHWAY

Reactome: R-HSA-148325520 genes29 compounds

The PI Metabolism pathway (Reactome ID: R-HSA-1483255) involves 20 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BMX INPPL1 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIP4K2A PIP5K1A SYNJ2

Compounds Affecting PI Metabolism

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Wortmannin	—	300
3	ly294002	—	11
4	torin 1	—	10
5	Sirolimus	—	300
6	alpelisib	—	227
7	Crizotinib	—	298
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	piceatannol	—	300
10	Quercetin	—	300
11	Adenosine	—	298
12	Kaempferols	—	300
13	Thyroxine	—	994
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Diiodotyrosine	—	300
16	Disulfiram	—	297
17	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
18	gamma-Linolenic Acid	—	300
19	Methyldopa	—	297
20	Masoprocol	—	300
21	Oxytetracycline	—	300
22	rafoxanide	—	172
23	Thyroxine	—	300
24	Ku 0063794 [Supplementary Concept]	—	7
25	Resveratrol	—	298
26	Aurintricarboxylic Acid	—	184
27	Gemfibrozil	—	297
28	Iodoacetamide	—	300
29	Chlorhexidine	—	299

About the PI Metabolism Pathway

The PI Metabolism pathway is catalogued in Reactome (ID: R-HSA-1483255) and involves 20 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BMX, INPPL1, PI4K2A, PI4K2B, PI4KA.