What compounds affect the DAG and IP3 signaling pathway?

77 compounds in the BiohacksAI corpus have documented interactions with genes in the DAG and IP3 signaling pathway (Reactome ID: R-HSA-1489509). These compounds target 14 genes within this pathway.

What genes are in the DAG and IP3 signaling pathway?

The DAG and IP3 signaling pathway involves 14 genes. Key genes include: ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1, GRK2, PDE1A, PDE1B, PDE1C.

DAG and IP3 signaling

REACTOME PATHWAY

Reactome: R-HSA-148950914 genes77 compounds

The DAG and IP3 signaling pathway (Reactome ID: R-HSA-1489509) involves 14 genes and is affected by 77 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1 GRK2 PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKX

Compounds Affecting DAG and IP3 signaling

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	sp600125	—	117
3	vinpocetine	—	299
4	Papaverine	—	299
5	Disulfiram	—	297
6	Quercetin	—	300
7	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
8	Aurintricarboxylic Acid	—	184
9	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
10	Axitinib	—	298
11	cycloheximide	—	300
12	Azacitidine	—	298
13	Azacitidine	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Levalbuterol	—	1,000
16	Adenosine Monophosphate Adenine nucleotide containing	—	300
17	Levalbuterol	—	297
18	Bortezomib	—	300
19	Clofarabine	—	298
20	Dactinomycin	—	297
21	Danazol	—	298
22	Emetine	—	298
23	Ethidium	—	300
24	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
25	Sulbactam	—	299
26	trequinsin hydrochloride	—	1
27	chrysin	—	300
28	Genistein	—	300
29	Testosterone	—	299
30	Ciclopirox	—	88
31	Cladribine	—	297
32	Clenbuterol	—	300
33	Corticosterone	—	300
34	Dasatinib	—	299
35	Daunorubicin	—	298
36	Dinoprostone	—	296
37	Epinephrine	—	299
38	Ethinyl Estradiol	—	300
39	Imatinib Mesylate	—	300
40	Nisoldipine	—	297
41	Nocodazole Nocodazole is	—	215
42	Masoprocol	—	300
43	Norepinephrine Precursor of epinephrine that is secreted by	—	298
44	o-Phthalaldehyde	—	300
45	Oxyphenbutazone	—	300
46	pivampicillin	—	275
47	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
48	Salmeterol Xinafoate	—	227
49	Tilorone	—	300
50	Urea	—	297

About the DAG and IP3 signaling Pathway

The DAG and IP3 signaling pathway is catalogued in Reactome (ID: R-HSA-1489509) and involves 14 genes. In the BiohacksAI corpus, 77 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2.