What compounds affect the Metabolism of nucleotides pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of nucleotides pathway (Reactome ID: R-HSA-15869). These compounds target 22 genes within this pathway.

What genes are in the Metabolism of nucleotides pathway?

The Metabolism of nucleotides pathway involves 22 genes. Key genes include: ADA, ADK, AMPD3, ATIC, CDA, DCK, DHODH, DTYMK, ENTPD5, GART.

Metabolism of nucleotides

REACTOME PATHWAY

Reactome: R-HSA-1586922 genes48 compounds

The Metabolism of nucleotides pathway (Reactome ID: R-HSA-15869) involves 22 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADA ADK AMPD3 ATIC CDA DCK DHODH DTYMK ENTPD5 GART GDA GSR HPRT1 IMPDH1 IMPDH2 PNP RRM1 RRM2 SAMHD1 TK1 TYMS XDH

Compounds Affecting Metabolism of nucleotides

#	Compound	Targets Hit	Studies
1	Pemetrexed	—	299
2	Methotrexate	—	289
3	Cytarabine	—	297
4	Thymidine Monophosphate 5-Thymidylic acid.	—	202
5	Gemcitabine	—	300
6	Inosine Monophosphate Inosine 5'-Monophosphate.	—	299
7	Adenosine	—	298
8	Coformycin	—	171
9	Clofarabine	—	298
10	Hydroxyurea	—	300
11	guanine	—	299
12	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
13	Febuxostat	—	297
14	Quercetin	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	chrysin	—	300
18	Oxypurinol	—	300
19	fisetin	—	78
20	Genistein	—	300
21	Kaempferols	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Hesperidin	—	300
24	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
25	Fluorodeoxyuridylate 5-Fluoro-2'-deoxyuridylate.	—	102
26	Capecitabine	—	297
27	Trifluridine	—	295
28	Deoxycytidine	—	300
29	Cladribine	—	297
30	Cytidine	—	300
31	Caffeine	—	299
32	Aminoimidazole Carboxamide	—	121
33	Uric Acid	—	298
34	Xanthine	—	298
35	Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is	—	210
36	Afatinib	—	297
37	Tubercidin	—	300
38	Methylene Blue	—	200
39	Carmustine	—	297
40	Meloxicam	—	299
41	Pentostatin	—	297
42	Bromodeoxyuridine	—	300
43	Vidarabine	—	299
44	Guanosine Monophosphate	—	300
45	Tetrahydrouridine	—	166
46	Uridine	—	300
47	Anthralin	—	299
48	Leflunomide	—	297

About the Metabolism of nucleotides Pathway

The Metabolism of nucleotides pathway is catalogued in Reactome (ID: R-HSA-15869) and involves 22 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADA, ADK, AMPD3, ATIC, CDA.