What compounds affect the Mitochondrial biogenesis pathway?

317 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitochondrial biogenesis pathway (Reactome ID: R-HSA-1592230). These compounds target 22 genes within this pathway.

What genes are in the Mitochondrial biogenesis pathway?

The Mitochondrial biogenesis pathway involves 22 genes. Key genes include: CARM1, CREB1, CREBBP, ESRRA, HDAC3, MAPK11, MAPK12, MAPK14, NCOA1, NCOR1.

Mitochondrial biogenesis

REACTOME PATHWAY

Reactome: R-HSA-159223022 genes317 compounds

The Mitochondrial biogenesis pathway (Reactome ID: R-HSA-1592230) involves 22 genes and is affected by 317 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREB1 CREBBP ESRRA HDAC3 MAPK11 MAPK12 MAPK14 NCOA1 NCOR1 NR1D1 POLRMT PPARA PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RXRA SIRT3 SIRT5

Compounds Affecting Mitochondrial biogenesis

#	Compound	Targets Hit	Studies
1	Rotenone	—	300
2	Niclosamide	—	299
3	Adenosine Monophosphate Adenine nucleotide containing	—	300
4	Ursolic Acid	—	300
5	Berberine	—	300
6	Proguanil	—	299
7	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
8	Antimycin	—	300
9	Oleanolic Acid	—	300
10	Metformin	—	1,000
11	Quercetin	—	300
12	Dasatinib	—	299
13	Anisomycin	—	247
14	Genistein	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	cycloheximide	—	300
18	Ethidium	—	300
19	Bortezomib	—	300
20	Celecoxib	—	295
21	Nocodazole Nocodazole is	—	215
22	Testosterone	—	299
23	Dactinomycin	—	297
24	Daunorubicin	—	298
25	Gemfibrozil	—	297
26	Aldosterone	—	300
27	Sorafenib	—	300
28	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
29	withaferin	—	300
30	Fulvestrant	—	295
31	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Methotrexate	—	289
34	Disulfiram	—	297
35	Flutamide	—	298
36	Hexachlorophene	—	300
37	Methylene Blue	—	200
38	Dihydrotestosterone	—	300
39	Progesterone	—	299
40	chrysin	—	300
41	Danazol	—	298
42	Fenofibrate	—	297
43	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
44	Nisoldipine	—	297
45	trequinsin hydrochloride	—	1
46	tyrphostin ag 1478	—	4
47	Cilostazol	—	297
48	Cladribine	—	297
49	Clofarabine	—	298
50	Corticosterone	—	300

About the Mitochondrial biogenesis Pathway

The Mitochondrial biogenesis pathway is catalogued in Reactome (ID: R-HSA-1592230) and involves 22 genes. In the BiohacksAI corpus, 317 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREB1, CREBBP, ESRRA, HDAC3.