What compounds target ESRRA?

BiohacksAI has identified 227 compounds that interact with ESRRA (estrogen related receptor alpha). Top compounds include: Genistein, Resveratrol, Fulvestrant, Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against, Pueraria. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ESRRA (estrogen related receptor)?

ESRRA is estrogen related receptor alpha. It is a molecular target for 227 compounds documented in PubMed bioassay data. UniProt ID: P11474. NCBI Gene ID: 2101.

ESRRA

MOLECULAR TARGET

estrogen related receptor alpha

UniProt: P11474 NCBI Gene: 2101227 compounds

ESRRA (estrogen related receptor alpha) is targeted by 227 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ESRRA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Genistein	2.83	16
2	Resveratrol	2.71	14
3	Fulvestrant	2.64	13
4	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	2.56	12
5	Pueraria	2.48	11
6	Apigenin 5,7,4'-trihydroxy-flavone,	2.40	10
7	Finasteride	2.40	10
8	Rotenone	2.40	10
9	Methotrexate	2.30	9
10	Disulfiram	2.30	9
11	Flutamide	2.30	9
12	Leflunomide	2.30	9
13	Niclosamide	2.30	9
14	Chlorhexidine	2.20	8
15	Hexachlorophene	2.20	8
16	Azacitidine	2.08	7
17	Azacitidine	2.08	7
18	Clotrimazole	2.08	7
19	Melengestrol Acetate	2.08	7
20	Reserpine	2.08	7
21	Methylene Blue	1.95	6
22	Androstenedione	1.95	6
23	Bromodeoxyuridine	1.95	6
24	cycloheximide	1.95	6
25	Dihydrotestosterone	1.95	6
26	Ethidium	1.95	6
27	Lovastatin	1.95	6
28	mg624	1.95	6
29	Nitrofurantoin	1.95	6
30	Budesonide	1.79	5
31	Dehydroepiandrosterone	1.79	5
32	Progesterone	1.79	5
33	propyl gallate	1.79	5
34	17-alpha-Hydroxyprogesterone	1.79	5
35	Dehydroepiandrosterone	1.79	5
36	Medroxyprogesterone Acetate	1.79	5
37	Megestrol Acetate Megestrol acetate is	1.79	5
38	Ouabain	1.79	5
39	Oxymetholone	1.79	5
40	Phenelzine	1.79	5
41	Phenoxybenzamine	1.79	5
42	Riluzole	1.79	5
43	chrysin	1.61	4
44	Simvastatin	1.61	4
45	2-Acetylaminofluorene	1.61	4
46	6-Aminonicotinamide	1.61	4
47	Acetaldehyde	1.61	4
48	amlexanox	1.61	4
49	Axitinib	1.61	4
50	Bortezomib	1.61	4

Showing top 50 of 227 compounds. Use the BiohacksAI search to explore all ESRRA modulators.

About ESRRA as a Drug Target

ESRRA (estrogen related receptor alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 227 compounds with documented ESRRA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ESRRA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.