What compounds affect the HIV Infection pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the HIV Infection pathway (Reactome ID: R-HSA-162906). These compounds target 50 genes within this pathway.

What genes are in the HIV Infection pathway?

The HIV Infection pathway involves 50 genes. Key genes include: ADRM1, APOBEC3G, CCNT2, CDK7, CDK9, ERCC3, FEN1, FURIN, FYN, HCK.

HIV Infection

REACTOME PATHWAY

Reactome: R-HSA-16290650 genes71 compounds

The HIV Infection pathway (Reactome ID: R-HSA-162906) involves 50 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 APOBEC3G CCNT2 CDK7 CDK9 ERCC3 FEN1 FURIN FYN HCK HLA-A KPNB1 LCK NPM1 PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1+20 more

Compounds Affecting HIV Infection

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Sorafenib	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Crizotinib	—	298
8	Dasatinib	—	299
9	kenpaullone	—	8
10	tyrphostin ag 1478	—	4
11	Quercetin	—	300
12	Ethidium	—	300
13	Levodopa	—	297
14	Methyldopa	—	297
15	piceatannol	—	300
16	Methylene Blue	—	200
17	streptonigrin	—	299
18	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
19	egcg	—	300
20	Genistein	—	300
21	Acetic Acid Product of	—	300
22	Afatinib	—	297
23	Aurintricarboxylic Acid	—	184
24	Norepinephrine Precursor of epinephrine that is secreted by	—	298
25	Dequalinium	—	136
26	Diiodotyrosine	—	300
27	Epinephrine	—	299
28	Idarubicin	—	299
29	Doxycycline	—	999
30	Carmine Coloring matter from	—	300
31	Cisplatin	—	300
32	Demeclocycline	—	297
33	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
34	Oxytetracycline	—	300
35	Cefixime	—	300
36	Biotin	—	297
37	furylfuramide	—	82
38	Demeclocycline	—	5
39	Edaravone	—	298
40	alphitonin [Supplementary Concept] from	—	300
41	Anthralin	—	299
42	sulfameter	—	52
43	DEAD-box RNA Helicases	—	169
44	Thioctic Acid	—	298
45	Resveratrol	—	298
46	Cefotetan	—	299
47	Dimethylphenylpiperazinium Iodide	—	33
48	mg624	—	3
49	Thioctic Acid	—	300
50	Disulfiram	—	297

About the HIV Infection Pathway

The HIV Infection pathway is catalogued in Reactome (ID: R-HSA-162906) and involves 50 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, APOBEC3G, CCNT2, CDK7, CDK9.