What compounds affect the Sphingolipid de novo biosynthesis pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Sphingolipid de novo biosynthesis pathway (Reactome ID: R-HSA-1660661). These compounds target 12 genes within this pathway.

What genes are in the Sphingolipid de novo biosynthesis pathway?

The Sphingolipid de novo biosynthesis pathway involves 12 genes. Key genes include: ABCC1, ABCG2, CSNK1G2, OSBP, PRKD1, PRKD2, PRKD3, SPHK1, SPHK2, SPTLC1.

Sphingolipid de novo biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-166066112 genes41 compounds

The Sphingolipid de novo biosynthesis pathway (Reactome ID: R-HSA-1660661) involves 12 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCG2 CSNK1G2 OSBP PRKD1 PRKD2 PRKD3 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3

Compounds Affecting Sphingolipid de novo biosynthesis

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	hydroxyfasudil [Supplementary Concept]	—	11
3	Crizotinib	—	298
4	sp600125	—	117
5	myriocin	—	80
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Daunorubicin	—	298
9	Delavirdine	—	296
10	Sphingosine	—	300
11	licochalcone	—	267
12	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
13	chrysin	—	300
14	Genistein	—	300
15	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
16	Atorvastatin	—	1,000
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Sirolimus	—	300
19	Avapritinib	—	246
20	candesartan cilexetil [Supplementary Concept]	—	300
21	Caspofungin	—	299
22	Estrone	—	300
23	Febuxostat	—	297
24	Fenofibrate	—	297
25	Furosemide	—	298
26	Sorafenib	—	300
27	Topotecan	—	300
28	Rimonabant	—	300
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Kaempferols	—	300
31	Abacavir	—	295
32	Dehydroepiandrosterone Sulfate	—	300
33	Emtricitabine	—	292
34	Flurandrenolone	—	65
35	Indomethacin	—	297
36	Lamivudine	—	299
37	tiopronin	—	299
38	Triamcinolone	—	300
39	Triamcinolone Acetonide	—	300
40	alsterpaullone	—	12
41	Cholesterol	—	300

About the Sphingolipid de novo biosynthesis Pathway

The Sphingolipid de novo biosynthesis pathway is catalogued in Reactome (ID: R-HSA-1660661) and involves 12 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCG2, CSNK1G2, OSBP, PRKD1.