What compounds affect the NOD1/2 Signaling Pathway pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the NOD1/2 Signaling Pathway pathway (Reactome ID: R-HSA-168638). These compounds target 16 genes within this pathway.

What genes are in the NOD1/2 Signaling Pathway pathway?

The NOD1/2 Signaling Pathway pathway involves 16 genes. Key genes include: CASP1, CASP2, CASP4, CASP9, CHUK, IKBKB, IRAK1, MAP3K7, MAPK11, MAPK12.

NOD1/2 Signaling Pathway

REACTOME PATHWAY

Reactome: R-HSA-16863816 genes55 compounds

The NOD1/2 Signaling Pathway pathway (Reactome ID: R-HSA-168638) involves 16 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CASP2 CASP4 CASP9 CHUK IKBKB IRAK1 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 NOD1 NOD2 RIPK2 UBE2N

Compounds Affecting NOD1/2 Signaling Pathway

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Anisomycin	—	247
3	Afatinib	—	297
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	withaferin	—	300
6	Crizotinib	—	298
7	Dasatinib	—	299
8	Camptothecin	—	300
9	Digitoxin	—	300
10	Digoxin	—	299
11	Disulfiram	—	297
12	Hexachlorophene	—	300
13	Ouabain	—	300
14	Thioridazine	—	35
15	Oxyphenbutazone	—	300
16	Axitinib	—	298
17	cycloheximide	—	300
18	alsterpaullone	—	12
19	chicoric acid	—	117
20	sp600125	—	117
21	felbinac	—	31
22	egcg	—	300
23	fisetin	—	78
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Quercetin	—	300
26	Celecoxib	—	295
27	tyrphostin ag 1478	—	4
28	Calcimycin	—	216
29	Calcitriol	—	300
30	cardamonin	—	180
31	dihydrorotenone	—	13
32	Tripterygium	—	300
33	cbd	—	298
34	Dehydroepiandrosterone Sulfate	—	300
35	cannabidiol	—	296
36	Ethinyl Estradiol	—	300
37	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
38	Norethynodrel	—	299
39	naringin	—	300
40	Chlorhexidine	—	299
41	Perphenazine	—	297
42	Sphingosine	—	300
43	Resveratrol	—	298
44	Sertraline	—	1,000
45	Astemizole Antihistamine drug now withdrawn from	—	280
46	Canrenone	—	300
47	Vemurafenib	—	298
48	Adenosine	—	298
49	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
50	Adenosine Triphosphate	—	300

About the NOD1/2 Signaling Pathway Pathway

The NOD1/2 Signaling Pathway pathway is catalogued in Reactome (ID: R-HSA-168638) and involves 16 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CASP2, CASP4, CASP9, CHUK.