Regulation of APC/C activators between G1/S and early anaphase

Q: What compounds affect the Regulation of APC/C activators between G1/S and early anaphase pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of APC/C activators between G1/S and early anaphase pathway (Reactome ID: R-HSA-176408). These compounds target 38 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-17640838 genes41 compounds

The Regulation of APC/C activators between G1/S and early anaphase pathway (Reactome ID: R-HSA-176408) involves 38 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNA1 CCNB1 CDK1 CDK2 CUL1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+8 more

Compounds Affecting Regulation of APC/C activators between G1/S and early anaphase

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	chrysin	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Quercetin	—	300
9	sp600125	—	117
10	indirubin	—	300
11	fisetin	—	78
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Disulfiram	—	297
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	Clofibrate	—	299
16	Fenofibrate	—	297
17	Sertraline	—	1,000
18	Cinnarizine	—	299
19	Clotrimazole	—	296
20	Rotenone	—	300
21	Sorafenib	—	300
22	ly294002	—	11
23	Wortmannin	—	300
24	Oleic Acid	—	112
25	Simvastatin	—	1,000
26	cefaclor	—	299
27	Hexachlorophene	—	300
28	Lithocholic Acid	—	300
29	Nisoldipine	—	297
30	Oxyphenbutazone	—	300
31	Oxytetracycline	—	300
32	4-Hydroxybenzoate-3-Monooxygenase	—	300
33	egcg	—	300
34	Genistein	—	300
35	Aurintricarboxylic Acid	—	184
36	Methylergonovine	—	14
37	candesartan cilexetil [Supplementary Concept]	—	300
38	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
39	ninhydrin	—	300
40	Pioglitazone	—	297
41	Harmaline	—	300

About the Regulation of APC/C activators between G1/S and early anaphase Pathway

The Regulation of APC/C activators between G1/S and early anaphase pathway is catalogued in Reactome (ID: R-HSA-176408) and involves 38 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CCNB1, CDK1, CDK2.