What compounds affect the Regulation of beta-cell development pathway?

66 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of beta-cell development pathway (Reactome ID: R-HSA-186712). These compounds target 12 genes within this pathway.

What genes are in the Regulation of beta-cell development pathway?

The Regulation of beta-cell development pathway involves 12 genes. Key genes include: AKT3, CREBBP, EP300, GCK, HNF4A, HNF4G, INS, KAT2A, KAT2B, NR5A2.

Regulation of beta-cell development

REACTOME PATHWAY

Reactome: R-HSA-18671212 genes66 compounds

The Regulation of beta-cell development pathway (Reactome ID: R-HSA-186712) involves 12 genes and is affected by 66 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CREBBP EP300 GCK HNF4A HNF4G INS KAT2A KAT2B NR5A2 PKLR SLC2A2

Compounds Affecting Regulation of beta-cell development

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Digoxin	—	299
3	Aldosterone	—	300
4	Triiodothyronine	—	300
5	Aurintricarboxylic Acid	—	184
6	plumbagin [Supplementary Concept]	—	300
7	egcg	—	300
8	Anisomycin	—	247
9	Azacitidine	—	298
10	Azacitidine	—	300
11	cycloheximide	—	300
12	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
13	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
14	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
15	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
16	Tubercidin	—	300
17	tyrphostin 9	—	2
18	Methylene Blue	—	200
19	Methotrexate	—	289
20	Cilostazol	—	297
21	clofilium tosylate	—	4
22	dihydrorotenone	—	13
23	Ethidium	—	300
24	Gemfibrozil	—	297
25	vinblastine sulfate	—	81
26	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
27	DEAD-box RNA Helicases	—	169
28	Thioctic Acid	—	298
29	Arachidonic Acid	—	245
30	Oleic Acid	—	112
31	alpha-Linolenic Acid	—	300
32	candesartan cilexetil [Supplementary Concept]	—	300
33	Cisplatin	—	300
34	diallyl trisulfide	—	246
35	Estramustine	—	300
36	gamma-Linolenic Acid	—	300
37	Hexachlorophene	—	300
38	Iodoacetamide	—	300
39	Lithocholic Acid	—	300
40	Oxytetracycline	—	300
41	rafoxanide	—	172
42	Ritonavir	—	298
43	Thioctic Acid	—	300
44	Trazodone	—	297
45	gedunin	—	54
46	hydroxyindoleacetic acid	—	300
47	Linoleic Acid	—	300
48	Nisoldipine	—	297
49	Oxyphenbutazone	—	300
50	Wortmannin	—	300

About the Regulation of beta-cell development Pathway

The Regulation of beta-cell development pathway is catalogued in Reactome (ID: R-HSA-186712) and involves 12 genes. In the BiohacksAI corpus, 66 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CREBBP, EP300, GCK, HNF4A.