What compounds affect the Heme biosynthesis pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the Heme biosynthesis pathway (Reactome ID: R-HSA-189451). These compounds target 3 genes within this pathway.

What genes are in the Heme biosynthesis pathway?

The Heme biosynthesis pathway involves 3 genes. Key genes include: ABCG2, ALB, FECH.

Heme biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-1894513 genes35 compounds

The Heme biosynthesis pathway (Reactome ID: R-HSA-189451) involves 3 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ALB FECH

Compounds Affecting Heme biosynthesis

#	Compound	Targets Hit	Studies
1	licochalcone	—	267
2	Quercetin	—	300
3	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	Genistein	—	300
7	Kaempferols	—	300
8	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
9	Atorvastatin	—	1,000
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Sirolimus	—	300
12	Avapritinib	—	246
13	candesartan cilexetil [Supplementary Concept]	—	300
14	Caspofungin	—	299
15	Daunorubicin	—	298
16	Delavirdine	—	296
17	Estrone	—	300
18	Febuxostat	—	297
19	Fenofibrate	—	297
20	Furosemide	—	298
21	Sorafenib	—	300
22	Topotecan	—	300
23	Warfarin	—	1,000
24	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
25	Tolbutamide	—	300
26	cbd	—	298
27	egcg	—	300
28	cannabidiol	—	296
29	Catechin	—	300
30	Evans Blue	—	300
31	Olmesartan Medoxomil	—	300
32	Phenylbutazone	—	300
33	Trazodone	—	297
34	Vemurafenib	—	298
35	Axitinib	—	298

About the Heme biosynthesis Pathway

The Heme biosynthesis pathway is catalogued in Reactome (ID: R-HSA-189451) and involves 3 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ALB, FECH.