What compounds affect the Regulated proteolysis of p75NTR pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulated proteolysis of p75NTR pathway (Reactome ID: R-HSA-193692). These compounds target 9 genes within this pathway.

What genes are in the Regulated proteolysis of p75NTR pathway?

The Regulated proteolysis of p75NTR pathway involves 9 genes. Key genes include: ADAM17, APH1A, APH1B, NCSTN, NFKB1, PSEN1, PSEN2, PSENEN, RELA.

Regulated proteolysis of p75NTR

REACTOME PATHWAY

Reactome: R-HSA-1936929 genes41 compounds

The Regulated proteolysis of p75NTR pathway (Reactome ID: R-HSA-193692) involves 9 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 APH1A APH1B NCSTN NFKB1 PSEN1 PSEN2 PSENEN RELA

Compounds Affecting Regulated proteolysis of p75NTR

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	Kaempferols	—	300
3	Quercetin	—	300
4	Resveratrol	—	298
5	Bortezomib	—	300
6	Podophyllotoxin	—	14
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	Trifluridine	—	295
14	withaferin	—	300
15	Hydrocortisone	—	299
16	egcg	—	300
17	Cerulenin	—	300
18	Chlorpropamide	—	300
19	daph	—	2
20	Disulfiram	—	297
21	Hexachlorophene	—	300
22	Hydrocortisone	—	298
23	Lovastatin	—	300
24	ly294002	—	11
25	Promethazine	—	121
26	protriptyline	—	296
27	streptonigrin	—	299
28	Sulfaphenazole	—	300
29	Triamcinolone	—	300
30	tyrphostin 1	—	1
31	tyrphostin ag 1478	—	4
32	Voriconazole	—	299
33	Cathelicidins Antimicrobial cationic peptides with	—	300
34	plumbagin [Supplementary Concept]	—	300
35	Ursolic Acid	—	300
36	chicoric acid	—	117
37	Oleanolic Acid	—	300
38	pyrrolidine dithiocarbamate	—	275
39	vinblastine sulfate	—	81
40	Bisphenol A-Glycidyl Methacrylate	—	197
41	Prednisolone	—	1,000

About the Regulated proteolysis of p75NTR Pathway

The Regulated proteolysis of p75NTR pathway is catalogued in Reactome (ID: R-HSA-193692) and involves 9 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, APH1A, APH1B, NCSTN, NFKB1.