What compounds target NFKB1?

BiohacksAI has identified 148 compounds that interact with NFKB1 (nuclear factor kappa B subunit 1). Top compounds include: andrographolide, psoralen, o coumaric acid, angelicin, rocaglamide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NFKB1 (nuclear factor kappa)?

NFKB1 is nuclear factor kappa B subunit 1. It is a molecular target for 148 compounds documented in PubMed bioassay data. UniProt ID: P19838. NCBI Gene ID: 4790.

NFKB1

MOLECULAR TARGET

nuclear factor kappa B subunit 1

UniProt: P19838 NCBI Gene: 4790148 compounds

NFKB1 (nuclear factor kappa B subunit 1) is targeted by 148 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NFKB1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	andrographolide	4.17	64
2	psoralen	3.26	25
3	o coumaric acid	3.09	21
4	angelicin	3.04	20
5	rocaglamide	2.89	17
6	cyclovalone	2.77	15
7	Quercetin	2.20	8
8	Resveratrol	1.39	3
9	Bortezomib	1.10	2
10	Podophyllotoxin	1.10	2
11	achyranthes bidentata	1.00	1
12	agastache rugosa	1.00	1
13	Garlic	1.00	1
14	aloe vera	1.00	1
15	arctium lappa	1.00	1
16	artemisia argyi	1.00	1
17	artemisia capillaris	1.00	1
18	atractylodes macrocephala	1.00	1
19	Centella	1.00	1
20	chaenomeles speciosa	1.00	1
21	cimicifuga heracleifolia	1.00	1
22	citrus reticulata	1.00	1
23	cnidium monnieri	1.00	1
24	crataegus pinnatifida	1.00	1
25	Curcuma	1.00	1
26	eucommia ulmoides	1.00	1
27	eupatorium fortunei	1.00	1
28	Foeniculum	1.00	1
29	forsythia suspensa	1.00	1
30	Ginkgo biloba	1.00	1
31	glycine max	1.00	1
32	lithospermum erythrorhizon	1.00	1
33	lonicera japonica	1.00	1
34	magnolia biondii	1.00	1
35	morus alba	1.00	1
36	Nelumbo	1.00	1
37	Panax	1.00	1
38	panax notoginseng	1.00	1
39	perilla frutescens	1.00	1
40	pinellia ternata	1.00	1
41	Piper nigrum	1.00	1
42	polygonum cuspidatum	1.00	1
43	prunella vulgaris	1.00	1
44	prunus armeniaca	1.00	1
45	prunus mume	1.00	1
46	prunus persica	1.00	1
47	Raphanus	1.00	1
48	rehmannia glutinosa	1.00	1
49	Rubia	1.00	1
50	salvia miltiorrhiza	1.00	1

Showing top 50 of 148 compounds. Use the BiohacksAI search to explore all NFKB1 modulators.

About NFKB1 as a Drug Target

NFKB1 (nuclear factor kappa B subunit 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 148 compounds with documented NFKB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NFKB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.