What genes are in the AKT phosphorylates targets in the cytosol pathway?

The AKT phosphorylates targets in the cytosol pathway involves 7 genes. Key genes include: AKT3, BAD, CASP9, CHUK, GSK3A, GSK3B, MDM2.

AKT phosphorylates targets in the cytosol

Q: What compounds affect the AKT phosphorylates targets in the cytosol pathway?

76 compounds in the BiohacksAI corpus have documented interactions with genes in the AKT phosphorylates targets in the cytosol pathway (Reactome ID: R-HSA-198323). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1983237 genes76 compounds

The AKT phosphorylates targets in the cytosol pathway (Reactome ID: R-HSA-198323) involves 7 genes and is affected by 76 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BAD CASP9 CHUK GSK3A GSK3B MDM2

Compounds Affecting AKT phosphorylates targets in the cytosol

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Chlorhexidine	—	299
3	Methylene Blue	—	200
4	Ursolic Acid	—	300
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	indirubin	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Kaempferols	—	300
11	Quercetin	—	300
12	chrysin	—	300
13	fisetin	—	78
14	egcg	—	300
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
16	Digoxin	—	299
17	Calcimycin	—	216
18	cycloheximide	—	300
19	Cytarabine	—	297
20	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
21	Niclosamide	—	299
22	Tubercidin	—	300
23	Anisomycin	—	247
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Azacitidine	—	298
26	Azacitidine	—	300
27	Ciclopirox	—	88
28	Cladribine	—	297
29	Colchicine	—	300
30	colchine	—	2
31	Demecolcine	—	246
32	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
33	Fluspirilene	—	74
34	gedunin	—	54
35	Hexachlorophene	—	300
36	lidoflazine	—	278
37	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
38	Nisoldipine	—	297
39	Nocodazole Nocodazole is	—	215
40	Ouabain	—	300
41	paxilline	—	42
42	Podophyllotoxin	—	14
43	rafoxanide	—	172
44	streptonigrin	—	299
45	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
46	Trifluridine	—	295
47	tyrphostin 9	—	2
48	vinblastine sulfate	—	81
49	Sertraline	—	1,000
50	Simvastatin	—	1,000

About the AKT phosphorylates targets in the cytosol Pathway

The AKT phosphorylates targets in the cytosol pathway is catalogued in Reactome (ID: R-HSA-198323) and involves 7 genes. In the BiohacksAI corpus, 76 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BAD, CASP9, CHUK, GSK3A.