What compounds target MDM2?

BiohacksAI has identified 52 compounds that interact with MDM2 (MDM2 proto-oncogene). Top compounds include: Digoxin, Calcimycin, cycloheximide, Cytarabine, Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MDM2 (MDM2 proto-oncogene)?

MDM2 is MDM2 proto-oncogene. It is a molecular target for 52 compounds documented in PubMed bioassay data. UniProt ID: Q00987. NCBI Gene ID: 4193.

MDM2

MOLECULAR TARGET

MDM2 proto-oncogene

UniProt: Q00987 NCBI Gene: 419352 compounds

MDM2 (MDM2 proto-oncogene) is targeted by 52 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MDM2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Digoxin	1.61	4
2	Calcimycin	1.39	3
3	cycloheximide	1.39	3
4	Cytarabine	1.39	3
5	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	1.39	3
6	Niclosamide	1.39	3
7	Tubercidin	1.39	3
8	Anisomycin	1.10	2
9	Astemizole Antihistamine drug now withdrawn from	1.10	2
10	Azacitidine	1.10	2
11	Azacitidine	1.10	2
12	Chlorhexidine	1.10	2
13	Ciclopirox	1.10	2
14	Cladribine	1.10	2
15	Colchicine	1.10	2
16	colchine	1.10	2
17	Demecolcine	1.10	2
18	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
19	Fluspirilene	1.10	2
20	gedunin	1.10	2
21	Hexachlorophene	1.10	2
22	lidoflazine	1.10	2
23	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.10	2
24	Nisoldipine	1.10	2
25	Nocodazole Nocodazole is	1.10	2
26	Ouabain	1.10	2
27	paxilline	1.10	2
28	Podophyllotoxin	1.10	2
29	rafoxanide	1.10	2
30	streptonigrin	1.10	2
31	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	1.10	2
32	Trifluridine	1.10	2
33	tyrphostin 9	1.10	2
34	vinblastine sulfate	1.10	2
35	Methylene Blue	0.69	1
36	Sertraline	0.69	1
37	Simvastatin	0.69	1
38	Ursolic Acid	0.69	1
39	Methotrexate	0.69	1
40	Aripiprazole	0.69	1
41	cardamonin	0.69	1
42	dihydrorotenone	0.69	1
43	Dinitrochlorobenzene	0.69	1
44	Lovastatin	0.69	1
45	Melphalan	0.69	1
46	Nitrofurantoin	0.69	1
47	Oxyphenbutazone	0.69	1
48	propionylpromazine hydrochloride	0.69	1
49	sp600125	0.69	1
50	Spironolactone	0.69	1

Showing top 50 of 52 compounds. Use the BiohacksAI search to explore all MDM2 modulators.

About MDM2 as a Drug Target

MDM2 (MDM2 proto-oncogene) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 52 compounds with documented MDM2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MDM2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.