What genes are in the Cell surface interactions at the vascular wall pathway?

The Cell surface interactions at the vascular wall pathway involves 26 genes. Key genes include: ATP1B1, ATP1B2, ATP1B3, CD47, CD74, FYN, GP6, GRB2, ITGA4, ITGAV.

Cell surface interactions at the vascular wall

Q: What compounds affect the Cell surface interactions at the vascular wall pathway?

75 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell surface interactions at the vascular wall pathway (Reactome ID: R-HSA-202733). These compounds target 26 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-20273326 genes75 compounds

The Cell surface interactions at the vascular wall pathway (Reactome ID: R-HSA-202733) involves 26 genes and is affected by 75 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP1B1 ATP1B2 ATP1B3 CD47 CD74 FYN GP6 GRB2 ITGA4 ITGAV ITGB2 ITGB3 LCK LYN MERTK MIF OLR1 PIK3CB PIK3R1 PIK3R2 PTPN6 SELE SIRPA SRC TEK YES1

Compounds Affecting Cell surface interactions at the vascular wall

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	Dasatinib	—	299
4	tyrphostin ag 1478	—	4
5	Axitinib	—	298
6	pictilisib	—	25
7	kenpaullone	—	8
8	Quercetin	—	300
9	ly294002	—	11
10	Sirolimus	—	300
11	Digoxin	—	299
12	Ouabain	—	300
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digitoxin	—	300
15	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
16	Resveratrol	—	298
17	Afatinib	—	297
18	alsterpaullone	—	12
19	Acetic Acid Product of	—	300
20	sp600125	—	117
21	Wortmannin	—	300
22	alpelisib	—	227
23	Aurintricarboxylic Acid	—	184
24	Histidine	—	158
25	Fusaric Acid	—	300
26	Idarubicin	—	299
27	Mimosine 3-Hydroxy-4-oxo-1(4H)-pyridinealanine.	—	300
28	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
29	Inositol	—	300
30	Phenylbutazone	—	300
31	Sulfinpyrazone	—	300
32	Chlorogenic Acid	—	300
33	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
34	Prednisolone	—	1,000
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Enoximone	—	300
37	Isocarboxazid	—	227
38	Oxaprozin	—	181
39	Quinestrol	—	194
40	Ranolazine	—	297
41	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
42	sulfameter	—	52
43	sulfamonomethoxine	—	253
44	Kaempferols	—	300
45	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
46	Cladribine	—	297
47	Pioglitazone	—	297
48	Vemurafenib	—	298
49	Adenosine Monophosphate Adenine nucleotide containing	—	300
50	monorden	—	8

About the Cell surface interactions at the vascular wall Pathway

The Cell surface interactions at the vascular wall pathway is catalogued in Reactome (ID: R-HSA-202733) and involves 26 genes. In the BiohacksAI corpus, 75 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP1B1, ATP1B2, ATP1B3, CD47, CD74.