What compounds affect the Gene Silencing by RNA pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Gene Silencing by RNA pathway (Reactome ID: R-HSA-211000). These compounds target 4 genes within this pathway.

What genes are in the Gene Silencing by RNA pathway?

The Gene Silencing by RNA pathway involves 4 genes. Key genes include: AGO2, HSP90AA1, RAN, TARBP2.

Gene Silencing by RNA

REACTOME PATHWAY

Reactome: R-HSA-2110004 genes33 compounds

The Gene Silencing by RNA pathway (Reactome ID: R-HSA-211000) involves 4 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 HSP90AA1 RAN TARBP2

Compounds Affecting Gene Silencing by RNA

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	triolimus [Supplementary Concept]	—	33
3	monorden	—	8
4	gedunin	—	54
5	celastrol	—	300
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	ag490	—	14
16	Calcimycin	—	216
17	Calcitriol	—	300
18	Ciclopirox	—	88
19	Clotrimazole	—	296
20	cycloheximide	—	300
21	deguelin [Supplementary Concept]	—	151
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Enoxacin	—	299
32	Reserpine	—	297
33	Sulfisomidine	—	73

About the Gene Silencing by RNA Pathway

The Gene Silencing by RNA pathway is catalogued in Reactome (ID: R-HSA-211000) and involves 4 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, HSP90AA1, RAN, TARBP2.