Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

Q: What compounds affect the Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 pathway?

230 compounds in the BiohacksAI corpus have documented interactions with genes in the Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 pathway (Reactome ID: R-HSA-211957). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-2119571 genes230 compounds

The Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 pathway (Reactome ID: R-HSA-211957) involves 1 genes and is affected by 230 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP1A2

Compounds Affecting Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

#	Compound	Targets Hit	Studies
1	Phenacetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Quercetin	—	300
4	Melatonin	—	297
5	Disulfiram	—	297
6	chrysin	—	300
7	Flutamide	—	298
8	Genistein	—	300
9	Kaempferols	—	300
10	Clotrimazole	—	296
11	Methoxsalen	—	300
12	Piribedil	—	300
13	Riluzole	—	298
14	Sulindac	—	297
15	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
16	Pueraria	—	300
17	Isoniazid Antibacterial agent used primarily as	—	299
18	Leflunomide	—	297
19	Nocodazole Nocodazole is	—	215
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	Clofibrate	—	299
22	Diuron	—	300
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	Ethoxyquin Antioxidant; also	—	180
25	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	—	300
26	Vitamin K 3	—	300
27	Miconazole	—	298
28	Niclosamide	—	299
29	Perphenazine	—	297
30	Quipazine	—	300
31	Tolazamide	—	169
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	Fenofibrate	—	297
34	tyrphostin ag 1478	—	4
35	Methylene Blue	—	200
36	propyl gallate	—	261
37	Anastrozole	—	298
38	Bufexamac	—	137
39	Camptothecin	—	300
40	Carbaryl	—	300
41	Carboxin	—	174
42	Dinitrochlorobenzene	—	300
43	Etazolate	—	66
44	Ethidium	—	300
45	fluoranthene	—	300
46	Linuron	—	299
47	ly294002	—	11
48	Melphalan	—	300
49	Mestranol	—	300
50	Nisoldipine	—	297

About the Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Pathway

The Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 pathway is catalogued in Reactome (ID: R-HSA-211957) and involves 1 genes. In the BiohacksAI corpus, 230 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP1A2.