What compounds affect the Separation of Sister Chromatids pathway?

61 compounds in the BiohacksAI corpus have documented interactions with genes in the Separation of Sister Chromatids pathway (Reactome ID: R-HSA-2467813). These compounds target 58 genes within this pathway.

What genes are in the Separation of Sister Chromatids pathway?

The Separation of Sister Chromatids pathway involves 58 genes. Key genes include: ADRM1, AURKB, BIRC5, HDAC8, PLK1, PPP1CC, PPP2CA, PPP2R5A, PSMA1, PSMA2.

Separation of Sister Chromatids

REACTOME PATHWAY

Reactome: R-HSA-246781358 genes61 compounds

The Separation of Sister Chromatids pathway (Reactome ID: R-HSA-2467813) involves 58 genes and is affected by 61 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AURKB BIRC5 HDAC8 PLK1 PPP1CC PPP2CA PPP2R5A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+28 more

Compounds Affecting Separation of Sister Chromatids

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Vorinostat	—	299
5	Vincristine	—	299
6	Noscapine	—	300
7	Reserpine	—	297
8	Podophyllotoxin	—	14
9	Demecolcine	—	246
10	Maytansine	—	300
11	vinblastine sulfate	—	81
12	Quercetin	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Okadaic Acid	—	300
15	Sorafenib	—	300
16	sp600125	—	117
17	Crizotinib	—	298
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Dasatinib	—	299
21	Disulfiram	—	297
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	fisetin	—	78
24	Axitinib	—	298
25	kenpaullone	—	8
26	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
27	Kaempferols	—	300
28	hydroxyfasudil [Supplementary Concept]	—	11
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
31	scutellarein	—	113
32	tamarixetin	—	26
33	ly294002	—	11
34	Wortmannin	—	300
35	Oleic Acid	—	112
36	Simvastatin	—	1,000
37	cefaclor	—	299
38	Hexachlorophene	—	300
39	Lithocholic Acid	—	300
40	Nisoldipine	—	297
41	Oxyphenbutazone	—	300
42	Oxytetracycline	—	300
43	4-Hydroxybenzoate-3-Monooxygenase	—	300
44	chrysin	—	300
45	egcg	—	300
46	Genistein	—	300
47	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
48	scriptaid	—	53
49	pictilisib	—	25
50	Valproic Acid	—	296

About the Separation of Sister Chromatids Pathway

The Separation of Sister Chromatids pathway is catalogued in Reactome (ID: R-HSA-2467813) and involves 58 genes. In the BiohacksAI corpus, 61 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKB, BIRC5, HDAC8, PLK1.