What compounds affect the Peptide ligand-binding receptors pathway?

239 compounds in the BiohacksAI corpus have documented interactions with genes in the Peptide ligand-binding receptors pathway (Reactome ID: R-HSA-375276). These compounds target 65 genes within this pathway.

What genes are in the Peptide ligand-binding receptors pathway?

The Peptide ligand-binding receptors pathway involves 65 genes. Key genes include: AGTR1, AGTR2, APLNR, APP, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, C5.

Peptide ligand-binding receptors

REACTOME PATHWAY

Reactome: R-HSA-37527665 genes239 compounds

The Peptide ligand-binding receptors pathway (Reactome ID: R-HSA-375276) involves 65 genes and is affected by 239 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGTR1 AGTR2 APLNR APP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 C5 CCKBR CCL2 CCR4 CCR6 CX3CR1 CXCL8 CXCR1 CXCR6 ECE1 EDNRA EDNRB F2RL1 FPR1 FPR2 FPR3 GALR2 GALR3 GHSR GPER1 GRPR+35 more

Compounds Affecting Peptide ligand-binding receptors

#	Compound	Targets Hit	Studies
1	Fluspirilene	—	74
2	Calcimycin	—	216
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Somatostatin	—	300
5	Carvedilol	—	296
6	Digoxin	—	299
7	Clotrimazole	—	296
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Methylene Blue	—	200
10	Disulfiram	—	297
11	Peptide YY	—	300
12	2-Chloroadenosine 2-Chloroadenosine.	—	300
13	Chlorhexidine	—	299
14	Hexachlorophene	—	300
15	Thioridazine	—	35
16	Somatostatin-28	—	299
17	Camptothecin	—	300
18	Fentanyl	—	300
19	Quercetin	—	300
20	candesartan cilexetil [Supplementary Concept]	—	300
21	Niclosamide	—	299
22	Substance P	—	299
23	Aripiprazole	—	298
24	Arginine Vasopressin	—	298
25	Oxytocin	—	299
26	Deamino Arginine Vasopressin	—	46
27	Ornipressin	—	82
28	Perphenazine	—	297
29	Octreotide	—	300
30	Morphine	—	294
31	Naloxone	—	299
32	Nalbuphine	—	298
33	Butorphanol	—	299
34	Oxycodone	—	298
35	Levorphanol	—	297
36	Nalorphine	—	300
37	Pentazocine	—	299
38	Diprenorphine	—	295
39	Sufentanil	—	298
40	Levallorphan	—	289
41	Meperidine	—	297
42	Codeine	—	295
43	Etorphine	—	300
44	cbd	—	298
45	cannabidiol	—	296
46	Dihydromorphine	—	300
47	Alfentanil	—	298
48	Hydromorphone	—	297
49	Cyclazocine	—	300
50	Kaempferols	—	300

About the Peptide ligand-binding receptors Pathway

The Peptide ligand-binding receptors pathway is catalogued in Reactome (ID: R-HSA-375276) and involves 65 genes. In the BiohacksAI corpus, 239 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGTR1, AGTR2, APLNR, APP, AVPR1A.