What compounds affect the Signaling by ROBO receptors pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ROBO receptors pathway (Reactome ID: R-HSA-376176). These compounds target 47 genes within this pathway.

What genes are in the Signaling by ROBO receptors pathway?

The Signaling by ROBO receptors pathway involves 47 genes. Key genes include: ABL1, ABL2, ADRM1, BUB1B-PAK6, CDC42, EIF4G1, PABPC1, PAK4, PAK5, PAK6.

Signaling by ROBO receptors

REACTOME PATHWAY

Reactome: R-HSA-37617647 genes55 compounds

The Signaling by ROBO receptors pathway (Reactome ID: R-HSA-376176) involves 47 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 ADRM1 BUB1B-PAK6 CDC42 EIF4G1 PABPC1 PAK4 PAK5 PAK6 PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3+17 more

Compounds Affecting Signaling by ROBO receptors

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Sorafenib	—	300
6	Axitinib	—	298
7	Dasatinib	—	299
8	Crizotinib	—	298
9	tyrphostin ag 1478	—	4
10	Quercetin	—	300
11	Oxytetracycline	—	300
12	egcg	—	300
13	hydroxyfasudil [Supplementary Concept]	—	11
14	Afatinib	—	297
15	Genistein	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	alpelisib	—	227
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Hexachlorophene	—	300
20	Avapritinib	—	246
21	Biotin	—	297
22	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
23	Imatinib Mesylate	—	300
24	triolimus [Supplementary Concept]	—	33
25	pterostilbene	—	299
26	Adenosine Triphosphate	—	300
27	Nocodazole Nocodazole is	—	215
28	Disulfiram	—	297
29	4-Hydroxybenzoate-3-Monooxygenase	—	300
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	chrysin	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Oxcarbazepine	—	296
34	Rosmarinic Acid	—	300
35	Rutin	—	300
36	Anthralin	—	299
37	Cefixime	—	300
38	Ethidium	—	300
39	Phenoxybenzamine	—	21
40	sp600125	—	117
41	Temozolomide	—	299
42	Resveratrol	—	298
43	Adenosine Monophosphate Adenine nucleotide containing	—	300
44	monorden	—	8
45	Niclosamide	—	299
46	DEAD-box RNA Helicases	—	169
47	Thioctic Acid	—	298
48	Thioctic Acid	—	300
49	Azauridine	—	300
50	Levetiracetam	—	296

About the Signaling by ROBO receptors Pathway

The Signaling by ROBO receptors pathway is catalogued in Reactome (ID: R-HSA-376176) and involves 47 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, ADRM1, BUB1B-PAK6, CDC42.