What compounds affect the Protein folding pathway?

178 compounds in the BiohacksAI corpus have documented interactions with genes in the Protein folding pathway (Reactome ID: R-HSA-391251). These compounds target 27 genes within this pathway.

What genes are in the Protein folding pathway?

The Protein folding pathway involves 27 genes. Key genes include: CCNE2, CCT2, CSNK2A1, CSNK2A2, CSNK2B, GBA1, GNA15, HDAC3, RGS7, SPHK1.

Protein folding

REACTOME PATHWAY

Reactome: R-HSA-39125127 genes178 compounds

The Protein folding pathway (Reactome ID: R-HSA-391251) involves 27 genes and is affected by 178 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNE2 CCT2 CSNK2A1 CSNK2A2 CSNK2B GBA1 GNA15 HDAC3 RGS7 SPHK1 STAT3 TP53 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6

Compounds Affecting Protein folding

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	vinblastine sulfate	—	81
5	Noscapine	—	300
6	Vincristine	—	299
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	Maytansine	—	300
10	Quercetin	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	chrysin	—	300
14	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
15	fisetin	—	78
16	Kaempferols	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Vanillic Acid	—	300
20	ly294002	—	11
21	Methylene Blue	—	200
22	Bortezomib	—	300
23	Niclosamide	—	299
24	Daunorubicin	—	298
25	Axitinib	—	298
26	Camptothecin	—	300
27	Genistein	—	300
28	sp600125	—	117
29	Adenosine Triphosphate	—	300
30	Astemizole Antihistamine drug now withdrawn from	—	280
31	Bisphenol A-Glycidyl Methacrylate	—	197
32	Chlorhexidine	—	299
33	alsterpaullone	—	12
34	kenpaullone	—	8
35	pictilisib	—	25
36	Celecoxib	—	295
37	Sphingosine	—	300
38	Ethidium	—	300
39	Ethinyl Estradiol	—	300
40	Hexachlorophene	—	300
41	Azacitidine	—	298
42	Azacitidine	—	300
43	Rotenone	—	300
44	Azathioprine	—	300
45	Cladribine	—	297
46	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
47	Cytarabine	—	297
48	Melphalan	—	300
49	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
50	Methotrexate	—	289

About the Protein folding Pathway

The Protein folding pathway is catalogued in Reactome (ID: R-HSA-391251) and involves 27 genes. In the BiohacksAI corpus, 178 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNE2, CCT2, CSNK2A1, CSNK2A2, CSNK2B.