What compounds affect the Eicosanoid ligand-binding receptors pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the Eicosanoid ligand-binding receptors pathway (Reactome ID: R-HSA-391903). These compounds target 14 genes within this pathway.

What genes are in the Eicosanoid ligand-binding receptors pathway?

The Eicosanoid ligand-binding receptors pathway involves 14 genes. Key genes include: CYSLTR1, CYSLTR2, GPR17, LTB4R, LTB4R2, OXER1, PTGDR, PTGDR2, PTGER1, PTGER2.

Eicosanoid ligand-binding receptors

REACTOME PATHWAY

Reactome: R-HSA-39190314 genes68 compounds

The Eicosanoid ligand-binding receptors pathway (Reactome ID: R-HSA-391903) involves 14 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYSLTR1 CYSLTR2 GPR17 LTB4R LTB4R2 OXER1 PTGDR PTGDR2 PTGER1 PTGER2 PTGER4 PTGFR PTGIR TBXA2R

Compounds Affecting Eicosanoid ligand-binding receptors

#	Compound	Targets Hit	Studies
1	Dinoprostone	—	296
2	Dinoprost	—	252
3	Prostaglandin D2	—	300
4	Alprostadil	—	297
5	Iloprost	—	300
6	Cloprostenol	—	300
7	Leukotriene C4	—	300
8	Leukotriene E4	—	300
9	Epoprostenol	—	297
10	Misoprostol	—	298
11	Irbesartan	—	298
12	Uridine Diphosphate	—	300
13	Leukotriene D4	—	300
14	Leukotriene B4	—	300
15	Celecoxib	—	295
16	Calcimycin	—	216
17	Disulfiram	—	297
18	Vitamin K 3	—	300
19	Nitroarginine	—	300
20	Methylene Blue	—	200
21	plumbagin [Supplementary Concept]	—	300
22	Levalbuterol	—	1,000
23	Levalbuterol	—	297
24	Carvedilol	—	296
25	celastrol	—	300
26	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
27	Cyclic AMP	—	300
28	Cyclic AMP	—	300
29	Hexachlorophene	—	300
30	Metaproterenol	—	298
31	Norepinephrine Precursor of epinephrine that is secreted by	—	298
32	Noscapine	—	300
33	p-Azobenzenearsonate	—	91
34	Salmeterol Xinafoate	—	227
35	Silymarin	—	300
36	trequinsin hydrochloride	—	1
37	Aripiprazole	—	298
38	Amlodipine	—	1,000
39	cbd	—	298
40	Losartan	—	1,000
41	Simvastatin	—	1,000
42	Axitinib	—	298
43	candesartan cilexetil [Supplementary Concept]	—	300
44	cannabidiol	—	296
45	Enoxacin	—	299
46	Epirubicin	—	300
47	Ezetimibe	—	296
48	Flutamide	—	298
49	Micafungin	—	300
50	Nicergoline	—	300

About the Eicosanoid ligand-binding receptors Pathway

The Eicosanoid ligand-binding receptors pathway is catalogued in Reactome (ID: R-HSA-391903) and involves 14 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYSLTR1, CYSLTR2, GPR17, LTB4R, LTB4R2.