What compounds affect the Adenosine P1 receptors pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Adenosine P1 receptors pathway (Reactome ID: R-HSA-417973). These compounds target 2 genes within this pathway.

What genes are in the Adenosine P1 receptors pathway?

The Adenosine P1 receptors pathway involves 2 genes. Key genes include: ADORA2B, ADORA3.

Adenosine P1 receptors

REACTOME PATHWAY

Reactome: R-HSA-4179732 genes43 compounds

The Adenosine P1 receptors pathway (Reactome ID: R-HSA-417973) involves 2 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADORA2B ADORA3

Compounds Affecting Adenosine P1 receptors

#	Compound	Targets Hit	Studies
1	2-Chloroadenosine 2-Chloroadenosine.	—	300
2	Adenosine	—	298
3	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
4	Bromocriptine	—	299
5	Troglitazone	—	299
6	Kinetin	—	300
7	Quercetin	—	300
8	same	—	299
9	Simvastatin	—	1,000
10	Vitamin K 2	—	300
11	Aripiprazole	—	298
12	Axitinib	—	298
13	Calcitriol	—	300
14	candesartan cilexetil [Supplementary Concept]	—	300
15	Celecoxib	—	295
16	Chlorhexidine	—	299
17	cinacalcet	—	298
18	Clotrimazole	—	296
19	Crizotinib	—	298
20	Cyclizine	—	251
21	Dequalinium	—	136
22	Desogestrel	—	299
23	Disulfiram	—	297
24	Ethynodiol Diacetate	—	300
25	Ezetimibe	—	296
26	Flunarizine Flunarizine is	—	299
27	Fluspirilene	—	74
28	Hexachlorophene	—	300
29	Loratadine	—	296
30	Meclizine	—	121
31	Mometasone Furoate	—	292
32	Nisoldipine	—	297
33	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
34	Oxymetholone	—	298
35	Pentostatin	—	297
36	Rimonabant	—	300
37	s adenosylmethionine	—	300
38	Sorafenib	—	300
39	Suramin	—	300
40	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
41	Thiethylperazine	—	165
42	Ticagrelor	—	299
43	Caffeine	—	299

About the Adenosine P1 receptors Pathway

The Adenosine P1 receptors pathway is catalogued in Reactome (ID: R-HSA-417973) and involves 2 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADORA2B, ADORA3.