What compounds affect the Signal transduction by L1 pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Signal transduction by L1 pathway (Reactome ID: R-HSA-445144). These compounds target 12 genes within this pathway.

What genes are in the Signal transduction by L1 pathway?

The Signal transduction by L1 pathway involves 12 genes. Key genes include: CSNK2A1, CSNK2A2, CSNK2B, EGFR, FGFR1, ITGA2B, ITGAV, ITGB3, MAP2K1, MAP2K2.

Signal transduction by L1

REACTOME PATHWAY

Reactome: R-HSA-44514412 genes42 compounds

The Signal transduction by L1 pathway (Reactome ID: R-HSA-445144) involves 12 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK2A1 CSNK2A2 CSNK2B EGFR FGFR1 ITGA2B ITGAV ITGB3 MAP2K1 MAP2K2 MAPK1 MAPK3

Compounds Affecting Signal transduction by L1

#	Compound	Targets Hit	Studies
1	pd98059	—	7
2	alsterpaullone	—	12
3	fisetin	—	78
4	Sorafenib	—	300
5	trametinib	—	296
6	Axitinib	—	298
7	Dasatinib	—	299
8	kenpaullone	—	8
9	sp600125	—	117
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	Quercetin	—	300
13	Kaempferols	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	chrysin	—	300
17	Vanillic Acid	—	300
18	ly294002	—	11
19	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
20	plumbagin [Supplementary Concept]	—	300
21	tyrphostin ag 1478	—	4
22	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
23	withaferin	—	300
24	Vemurafenib	—	298
25	Clotrimazole	—	296
26	Progesterone	—	299
27	2-Chloroadenosine 2-Chloroadenosine.	—	300
28	Benzalkonium Compounds	—	299
29	Calcimycin	—	216
30	daph	—	2
31	Diphenhydramine	—	14
32	ha1004	—	4
33	Lithocholic Acid	—	300
34	Loratadine	—	296
35	trequinsin hydrochloride	—	1
36	Dichlororibofuranosylbenzimidazole	—	26
37	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
38	pictilisib	—	25
39	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
40	Afatinib	—	297
41	ag490	—	14
42	tyrphostin 1	—	1

About the Signal transduction by L1 Pathway

The Signal transduction by L1 pathway is catalogued in Reactome (ID: R-HSA-445144) and involves 12 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK2A1, CSNK2A2, CSNK2B, EGFR, FGFR1.