What genes are in the activated TAK1 mediates p38 MAPK activation pathway?

The activated TAK1 mediates p38 MAPK activation pathway involves 10 genes. Key genes include: IRAK1, MAP2K3, MAP3K7, MAPK11, MAPK14, MAPKAPK2, NOD1, NOD2, RIPK2, UBE2N.

activated TAK1 mediates p38 MAPK activation

Q: What compounds affect the activated TAK1 mediates p38 MAPK activation pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the activated TAK1 mediates p38 MAPK activation pathway (Reactome ID: R-HSA-450302). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-45030210 genes41 compounds

The activated TAK1 mediates p38 MAPK activation pathway (Reactome ID: R-HSA-450302) involves 10 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IRAK1 MAP2K3 MAP3K7 MAPK11 MAPK14 MAPKAPK2 NOD1 NOD2 RIPK2 UBE2N

Compounds Affecting activated TAK1 mediates p38 MAPK activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Afatinib	—	297
3	Anisomycin	—	247
4	Crizotinib	—	298
5	Dasatinib	—	299
6	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
7	withaferin	—	300
8	Camptothecin	—	300
9	Digitoxin	—	300
10	Digoxin	—	299
11	Ouabain	—	300
12	Oxyphenbutazone	—	300
13	Axitinib	—	298
14	cycloheximide	—	300
15	Adenosine Triphosphate	—	300
16	egcg	—	300
17	fisetin	—	78
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Quercetin	—	300
20	Celecoxib	—	295
21	tyrphostin ag 1478	—	4
22	Calcimycin	—	216
23	Calcitriol	—	300
24	cardamonin	—	180
25	dihydrorotenone	—	13
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Tripterygium	—	300
29	naringin	—	300
30	Chlorhexidine	—	299
31	Perphenazine	—	297
32	Sphingosine	—	300
33	Resveratrol	—	298
34	Sertraline	—	1,000
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Canrenone	—	300
37	Thioridazine	—	35
38	Vemurafenib	—	298
39	Adenosine	—	298
40	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
41	alsterpaullone	—	12

About the activated TAK1 mediates p38 MAPK activation Pathway

The activated TAK1 mediates p38 MAPK activation pathway is catalogued in Reactome (ID: R-HSA-450302) and involves 10 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IRAK1, MAP2K3, MAP3K7, MAPK11, MAPK14.