Question 1

What compounds affect the JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 pathway?

Accepted Answer

43 compounds in the BiohacksAI corpus have documented interactions with genes in the JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 pathway (Reactome ID: R-HSA-450321). These compounds target 10 genes within this pathway.

Question 2

What genes are in the JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 pathway?

Accepted Answer

The JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1 pathway involves 10 genes. Key genes include: IRAK1, MAP2K4, MAP3K7, MAPK10, MAPK8, MAPK9, NOD1, NOD2, RIPK2, UBE2N.

#	Compound	Targets Hit	Studies
1	Anisomycin	—	247
2	Afatinib	—	297
3	Axitinib	—	298
4	Sorafenib	—	300
5	sp600125	—	117
6	pictilisib	—	25
7	cardamonin	—	180
8	Crizotinib	—	298
9	Camptothecin	—	300
10	Digitoxin	—	300
11	Digoxin	—	299
12	Ouabain	—	300
13	Oxyphenbutazone	—	300
14	cycloheximide	—	300
15	Vemurafenib	—	298
16	Hesperidin	—	300
17	Quercetin	—	300
18	fisetin	—	78
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
23	Calcimycin	—	216
24	Calcitriol	—	300
25	dihydrorotenone	—	13
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Tripterygium	—	300
29	naringin	—	300
30	Chlorhexidine	—	299
31	Perphenazine	—	297
32	Sphingosine	—	300
33	Resveratrol	—	298
34	Sertraline	—	1,000
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Canrenone	—	300
37	Thioridazine	—	35
38	Dasatinib	—	299
39	Adenosine	—	298
40	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
41	Adenosine Triphosphate	—	300
42	alsterpaullone	—	12
43	Genistein	—	300

BiohacksAI

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

Genes in this Pathway

Compounds Affecting JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

About the JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Pathway