What genes are in the AUF1 (hnRNP D0) binds and destabilizes mRNA pathway?

The AUF1 (hnRNP D0) binds and destabilizes mRNA pathway involves 38 genes. Key genes include: ADRM1, EIF4G1, HSPA1A, HSPA1B, HSPA8, HSPB1, PABPC1, PSMA1, PSMA2, PSMA3.

AUF1 (hnRNP D0) binds and destabilizes mRNA

Q: What compounds affect the AUF1 (hnRNP D0) binds and destabilizes mRNA pathway?

64 compounds in the BiohacksAI corpus have documented interactions with genes in the AUF1 (hnRNP D0) binds and destabilizes mRNA pathway (Reactome ID: R-HSA-450408). These compounds target 38 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-45040838 genes64 compounds

The AUF1 (hnRNP D0) binds and destabilizes mRNA pathway (Reactome ID: R-HSA-450408) involves 38 genes and is affected by 64 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 EIF4G1 HSPA1A HSPA1B HSPA8 HSPB1 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+8 more

Compounds Affecting AUF1 (hnRNP D0) binds and destabilizes mRNA

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Hexachlorophene	—	300
4	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
5	Ergosterol	—	300
6	Disulfiram	—	297
7	Phenoxybenzamine	—	21
8	Quercetin	—	300
9	egcg	—	300
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	Oxytetracycline	—	300
12	Adenosine Triphosphate	—	300
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	Vitamin	—	295
15	Bufotenin	—	93
16	Clotrimazole	—	296
17	Feprazone	—	63
18	Nocodazole Nocodazole is	—	215
19	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
20	Adapalene	—	296
21	alpha-Linolenic Acid	—	300
22	Ciclopirox	—	88
23	Danazol	—	298
24	eliprodil	—	33
25	Ethinyl Estradiol	—	300
26	Ethoxyquin Antioxidant; also	—	180
27	Idazoxan	—	300
28	Leflunomide	—	297
29	Linoleic Acid	—	300
30	Lithocholic Acid	—	300
31	Methimazole	—	295
32	Methylcholanthrene	—	300
33	Methylnitrosourea	—	300
34	Mometasone Furoate	—	292
35	Nisoldipine	—	297
36	Masoprocol	—	300
37	Oxymetholone	—	298
38	rafoxanide	—	172
39	Sulfathiazole	—	300
40	Toxaphene	—	299
41	Triamcinolone Acetonide	—	300
42	Troglitazone	—	299
43	vinblastine sulfate	—	81
44	4-Hydroxybenzoate-3-Monooxygenase	—	300
45	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
46	chrysin	—	300
47	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
48	Genistein	—	300
49	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
50	Oxcarbazepine	—	296

About the AUF1 (hnRNP D0) binds and destabilizes mRNA Pathway

The AUF1 (hnRNP D0) binds and destabilizes mRNA pathway is catalogued in Reactome (ID: R-HSA-450408) and involves 38 genes. In the BiohacksAI corpus, 64 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, EIF4G1, HSPA1A, HSPA1B, HSPA8.