What compounds affect the Mitophagy pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitophagy pathway (Reactome ID: R-HSA-5205647). These compounds target 10 genes within this pathway.

What genes are in the Mitophagy pathway?

The Mitophagy pathway involves 10 genes. Key genes include: CSNK2A1, CSNK2A2, CSNK2B, MAP1LC3A, MAP1LC3B, PRKN, SRC, TBK1, UBE2N, ULK1.

Mitophagy

REACTOME PATHWAY

Reactome: R-HSA-520564710 genes45 compounds

The Mitophagy pathway (Reactome ID: R-HSA-5205647) involves 10 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK2A1 CSNK2A2 CSNK2B MAP1LC3A MAP1LC3B PRKN SRC TBK1 UBE2N ULK1

Compounds Affecting Mitophagy

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Quercetin	—	300
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	fisetin	—	78
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	chrysin	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	kenpaullone	—	8
12	Crizotinib	—	298
13	alsterpaullone	—	12
14	Axitinib	—	298
15	Resveratrol	—	298
16	Novobiocin	—	300
17	Dichlororibofuranosylbenzimidazole	—	26
18	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
19	sp600125	—	117
20	pictilisib	—	25
21	Dasatinib	—	299
22	tyrphostin ag 1478	—	4
23	Sorafenib	—	300
24	Adenosine Monophosphate Adenine nucleotide containing	—	300
25	Afatinib	—	297
26	monorden	—	8
27	Niclosamide	—	299
28	naringin	—	300
29	Chlorhexidine	—	299
30	Perphenazine	—	297
31	Sphingosine	—	300
32	Sertraline	—	1,000
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Canrenone	—	300
35	Thioridazine	—	35
36	Genistein	—	300
37	amn082	—	29
38	Hexachlorophene	—	300
39	Medroxyprogesterone Acetate	—	299
40	Nitrendipine	—	299
41	Fluspirilene	—	74
42	Mestranol	—	300
43	Tolazamide	—	169
44	Trifluridine	—	295
45	amlexanox	—	96

About the Mitophagy Pathway

The Mitophagy pathway is catalogued in Reactome (ID: R-HSA-5205647) and involves 10 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK2A1, CSNK2A2, CSNK2B, MAP1LC3A, MAP1LC3B.