What genes are in the Aflatoxin activation and detoxification pathway?

The Aflatoxin activation and detoxification pathway involves 4 genes. Key genes include: CYP1A2, CYP2A13, CYP3A4, CYP3A5.

Aflatoxin activation and detoxification

Q: What compounds affect the Aflatoxin activation and detoxification pathway?

363 compounds in the BiohacksAI corpus have documented interactions with genes in the Aflatoxin activation and detoxification pathway (Reactome ID: R-HSA-5423646). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-54236464 genes363 compounds

The Aflatoxin activation and detoxification pathway (Reactome ID: R-HSA-5423646) involves 4 genes and is affected by 363 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP1A2 CYP2A13 CYP3A4 CYP3A5

Compounds Affecting Aflatoxin activation and detoxification

#	Compound	Targets Hit	Studies
1	Methoxsalen	—	300
2	cbd	—	298
3	cannabidiol	—	296
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	Melatonin	—	297
7	Disulfiram	—	297
8	chrysin	—	300
9	Flutamide	—	298
10	Genistein	—	300
11	Kaempferols	—	300
12	Clotrimazole	—	296
13	Piribedil	—	300
14	Riluzole	—	298
15	Sulindac	—	297
16	Pueraria	—	300
17	Isoniazid Antibacterial agent used primarily as	—	299
18	Leflunomide	—	297
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Clofibrate	—	299
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	Ethoxyquin Antioxidant; also	—	180
23	Vitamin K 3	—	300
24	Miconazole	—	298
25	Niclosamide	—	299
26	Tolazamide	—	169
27	tyrphostin ag 1478	—	4
28	Methylene Blue	—	200
29	Anastrozole	—	298
30	Camptothecin	—	300
31	Carbaryl	—	300
32	Etazolate	—	66
33	Ethidium	—	300
34	Melphalan	—	300
35	Mestranol	—	300
36	Nisoldipine	—	297
37	Phenelzine	—	297
38	Phenelzine	—	2
39	Piperonyl Butoxide	—	300
40	Propanil	—	293
41	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
42	Kaempferols	—	300
43	ag490	—	14
44	Chlorhexidine	—	299
45	Hesperidin	—	300
46	Iodoacetamide	—	300
47	kenpaullone	—	8
48	Papaverine	—	299
49	pd98059	—	7
50	sp600125	—	117

About the Aflatoxin activation and detoxification Pathway

The Aflatoxin activation and detoxification pathway is catalogued in Reactome (ID: R-HSA-5423646) and involves 4 genes. In the BiohacksAI corpus, 363 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP1A2, CYP2A13, CYP3A4, CYP3A5.