What compounds affect the Ion homeostasis pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Ion homeostasis pathway (Reactome ID: R-HSA-5578775). These compounds target 23 genes within this pathway.

What genes are in the Ion homeostasis pathway?

The Ion homeostasis pathway involves 23 genes. Key genes include: ABCC9, ASPH, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A1.

Ion homeostasis

REACTOME PATHWAY

Reactome: R-HSA-557877523 genes36 compounds

The Ion homeostasis pathway (Reactome ID: R-HSA-5578775) involves 23 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC9 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 CAMK2B CAMK2D DMPK FKBP1B FXYD2 NOS1 PRKACA RYR1 RYR2 RYR3 TNNI3

Compounds Affecting Ion homeostasis

#	Compound	Targets Hit	Studies
1	Digoxin	—	299
2	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
3	Ouabain	—	300
4	Digitoxin	—	300
5	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
6	Caffeine	—	299
7	Adenosine Triphosphate	—	300
8	Dantrolene Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in	—	298
9	Ryanodine	—	299
10	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
11	Suramin	—	300
12	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
13	sp600125	—	117
14	paxilline	—	42
15	Deslanoside Deacetyllanatoside C.	—	89
16	Nitroarginine	—	300
17	NG-Nitroarginine Methyl Ester	—	238
18	Arginine	—	300
19	Arginine	—	300
20	Guanethidine	—	300
21	Quercetin	—	300
22	Sorafenib	—	300
23	hydroxyindoleacetic acid	—	300
24	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
25	Niridazole	—	300
26	Oxytetracycline	—	300
27	alsterpaullone	—	12
28	Crizotinib	—	298
29	Dasatinib	—	299
30	Cromakalim	—	300
31	Glyburide	—	298
32	hydroxyfasudil [Supplementary Concept]	—	11
33	Sphingosine	—	300
34	Sirolimus	—	300
35	Plicamycin	—	72
36	Thapsigargin	—	300

About the Ion homeostasis Pathway

The Ion homeostasis pathway is catalogued in Reactome (ID: R-HSA-5578775) and involves 23 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC9, ASPH, ATP1A1, ATP1A2, ATP1A3.