What genes are in the Cargo trafficking to the periciliary membrane pathway?

The Cargo trafficking to the periciliary membrane pathway involves 21 genes. Key genes include: CCT2, HDAC6, MCHR1, SSTR3, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3E, TUBA4A.

Cargo trafficking to the periciliary membrane

Q: What compounds affect the Cargo trafficking to the periciliary membrane pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the Cargo trafficking to the periciliary membrane pathway (Reactome ID: R-HSA-5620920). These compounds target 21 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-562092021 genes48 compounds

The Cargo trafficking to the periciliary membrane pathway (Reactome ID: R-HSA-5620920) involves 21 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCT2 HDAC6 MCHR1 SSTR3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting Cargo trafficking to the periciliary membrane

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vorinostat	—	299
4	Vincristine	—	299
5	Noscapine	—	300
6	Podophyllotoxin	—	14
7	Demecolcine	—	246
8	Maytansine	—	300
9	vinblastine sulfate	—	81
10	Camptothecin	—	300
11	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
12	scriptaid	—	53
13	pictilisib	—	25
14	Valproic Acid	—	296
15	Daunorubicin	—	298
16	Ursolic Acid	—	300
17	Butyric Acid	—	300
18	Celecoxib	—	295
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	chrysin	—	300
21	Pueraria	—	300
22	fisetin	—	78
23	Genistein	—	300
24	Kaempferols	—	300
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	pterostilbene	—	299
28	Quercetin	—	300
29	Axitinib	—	298
30	Bufexamac	—	137
31	butein	—	158
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Febuxostat	—	297
34	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
35	Hesperidin	—	300
36	pd98059	—	7
37	piceatannol	—	300
38	sp600125	—	117
39	stx64	—	2
40	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
41	triflupromazine hydrochloride	—	12
42	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester [Supplementary Concept]	—	100
43	Somatostatin	—	300
44	Somatostatin-28	—	299
45	Octreotide	—	300
46	Sertraline	—	1,000
47	Thioridazine	—	35
48	Methylene Blue	—	200

About the Cargo trafficking to the periciliary membrane Pathway

The Cargo trafficking to the periciliary membrane pathway is catalogued in Reactome (ID: R-HSA-5620920) and involves 21 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, HDAC6, MCHR1, SSTR3, TUBA1A.