What compounds affect the Pyroptosis pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the Pyroptosis pathway (Reactome ID: R-HSA-5620971). These compounds target 8 genes within this pathway.

What genes are in the Pyroptosis pathway?

The Pyroptosis pathway involves 8 genes. Key genes include: CASP1, CASP4, CASP5, ELANE, GSDMD, HMGB1, IL1B, TP53.

Pyroptosis

REACTOME PATHWAY

Reactome: R-HSA-56209718 genes190 compounds

The Pyroptosis pathway (Reactome ID: R-HSA-5620971) involves 8 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CASP4 CASP5 ELANE GSDMD HMGB1 IL1B TP53

Compounds Affecting Pyroptosis

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Ethidium	—	300
3	Ethinyl Estradiol	—	300
4	Hexachlorophene	—	300
5	Bortezomib	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Niclosamide	—	299
8	Methotrexate	—	289
9	cycloheximide	—	300
10	Dinitrochlorobenzene	—	300
11	Spironolactone	—	298
12	Thioridazine	—	35
13	Carbazilquinone	—	48
14	Digitoxin	—	300
15	Digoxin	—	299
16	Harmaline	—	300
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
18	Nisoldipine	—	297
19	Oxyphenbutazone	—	300
20	sp600125	—	117
21	triflupromazine hydrochloride	—	12
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Bisphenol A-Glycidyl Methacrylate	—	197
24	Chlorhexidine	—	299
25	tyrphostin 9	—	2
26	felbinac	—	31
27	Azacitidine	—	298
28	Azacitidine	—	300
29	Methylene Blue	—	200
30	Rotenone	—	300
31	Azathioprine	—	300
32	Cladribine	—	297
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
34	Cytarabine	—	297
35	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
36	Melphalan	—	300
37	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
38	Dactinomycin	—	297
39	Daunorubicin	—	298
40	Glutaral	—	42
41	Vitamin K 3	—	300
42	Trifluridine	—	295
43	Quercetin	—	300
44	Axitinib	—	298
45	ninhydrin	—	300
46	o-Phthalaldehyde	—	300
47	Razoxane	—	154
48	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
49	plumbagin [Supplementary Concept]	—	300
50	Camptothecin	—	300

About the Pyroptosis Pathway

The Pyroptosis pathway is catalogued in Reactome (ID: R-HSA-5620971) and involves 8 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CASP4, CASP5, ELANE, GSDMD.